The Expression/Methylation Profile of Adipogenic and Inflammatory Transcription Factors in Adipose Tissue Are Linked to Obesity-Related Colorectal Cancer

• Published in: Cancers Vol. 11; no. 11; p. 1629
• Main Authors: Boughanem, Hatim, Cabrera-Mulero, Amanda, Hernández-Alonso, Pablo, Bandera-Merchán, Borja, Tinahones, Alberto, Tinahones, Francisco José, Morcillo, Sonsoles, Macias-Gonzalez, Manuel
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 24.10.2019; MDPI
• Subjects: Adipose tissue; Biomarkers; Body fat; Body mass index; Body weight; Carcinogenesis; CCAAT-enhancer binding protein; Colorectal cancer; Colorectal carcinoma; DNA methylation; Epigenetics; Gene expression; Inflammation; Lymphocytes B; Metabolism; Metastasis; Microenvironments; NF-κB protein; Obesity; Overweight; Peroxisome proliferator-activated receptors; Risk factors; Transcription factors; Trends; Tumors; NF-κB; colorectal cancer; PGC-1α; C/EBP-α; PPAR-γ; obesity; visceral adipose tissue

Obesity is well accepted as crucial risk factor that plays a critical role in the initiation and progression of colorectal cancer (CRC). More specifically, visceral adipose tissue (VAT) in people with obesity could produce chronic inflammation and an altered profile expression of key transcription f...