Hydroalkylation of Aniline with Pd-Al2O3 and NaCl-AlCl3

• Published in: Chemical & pharmaceutical bulletin Vol. 30; no. 3; pp. 777 - 781
• Main Authors: KAMIYAMA, TSUTOMU, ENOMOTO, SABURO, INOUE, MASAMI
• Format: Journal Article
• Language: English
• Published: Tokyo The Pharmaceutical Society of Japan 01.01.1982; Japan Science and Technology Agency
• Subjects: dicyclohexylamine

The hydroalkylation of aniline in a palladium-fused salt system was examined under hydrogen pressure. By using 0.5% Pd-Al2O3 and fused salt (NaCl-AlCl3), N-cyclohexylaniline (4) was formed as the main product at temperatures below 300°C ; at higher temperatures, the cyclohexyl group rearranged to fo...