An E460D Substitution in the NS5 Protein of Tick-Borne Encephalitis Virus Confers Resistance to the Inhibitor Galidesivir (BCX4430) and Also Attenuates the Virus for Mice - Eyer, Ludek; Nougairède, Antoine; Uhlířová, Marie; Driouich, Jean-Sélim; Zouharová, Darina; Valdés, James J.; Haviernik, Jan; Gould, Ernest A.; De Clercq, Erik; de Lamballerie, Xavier; Ruzek, Daniel (Journal of virology, 2019)
Keywords: Adenine - analogs & derivatives; Adenine - chemistry; Adenine - pharmacology; Adenosine - analogs & derivatives; Alleles; Amino Acid Substitution; Animals; Antiviral Agents - chemistry; Antiviral Agents - pharmacology; Cell Line; Disease Models, Animal; Drug Resistance, Microbial; Drug Resistance, Viral; Encephalitis Viruses, Tick-Borne - drug effects; Encephalitis Viruses, Tick-Borne - physiology; Encephalitis, Tick-Borne - drug therapy; Encephalitis, Tick-Borne - virology; Genotype; Human health and pathology; Infectious diseases; Life Sciences; Mice; Microbiology and Parasitology; Mutation; Pyrrolidines - chemistry; Pyrrolidines - pharmacology; Spotlight; Vaccines and Antiviral Agents; Viral Nonstructural Proteins - genetics; galidesivir; mutation; attenuation; drug resistance; BCX4430; tick-borne encephalitis virus