Absence of clinical relationship between oxidized low density lipoproteins and diabetic peripheral neuropathy: a case control study

• Published in: Lipids in health and disease Vol. 13; no. 1; p. 32
• Main Authors: Rosales-Hernandez, Alma, Cheung, Audrey, Podgorny, Peter, Chan, Cynthia, Toth, Cory
• Format: Journal Article
• Language: English
• Published: England BioMed Central 12.02.2014
• Subjects: Aged; Biomarkers - blood; Brain research; Cardiovascular disease; Case-Control Studies; Cholesterol; Diabetes; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - complications; Diabetic Neuropathies - blood; Diabetic Neuropathies - pathology; Female; Glycated Hemoglobin A - metabolism; Humans; Hyperglycemia; Kinases; Lipoproteins, LDL - blood; Low density lipoprotein; Male; Middle Aged; Neurosciences; Older people; Oxidative stress; Pain; Peripheral Nervous System Diseases - blood; Peripheral Nervous System Diseases - pathology; Plasma; Regression analysis; Risk Factors; Severity of Illness Index; Statins; Studies

The pathophysiology of diabetic peripheral neuropathy (DPN) is complex and uncertain. A potential comorbidity in diabetes mellitus (DM) that may contribute to greater severity of DPN is a lipid disorder, such as with elevated cholesterol, low density lipoproteins or triglycerides. Oxidized low densi...