Estradiol attenuates LPS-induced acute lung injury via induction of aquaporins AQP1 and AQP5

• Published in: European journal of inflammation Vol. 19
• Main Authors: Wang, Xiaobo, Zhou, Xiuyun, Xia, Xiumei, Zhang, Yili
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 2021; SAGE PUBLICATIONS, INC; SAGE Publishing
• Subjects: Aquaporins; Edema; Oxidative stress; lipopolysaccharide; acute lung injury; Aquaporin; estradiol
• ISSN: 2058-7392; 1721-727X; 2058-7392
• DOI: 10.1177/20587392211049197

Background Acute lung injury (ALI) is associated with increased inflammation and oxidative stress. Estradiol is produced by the ovaries and is the most active hormone of estrogen. Our aim was to investigate whether estradiol contributes to protect against lipopolysaccharide (LPS)-induced ALI via ind...