Clonality, Mutation and Kaposi Sarcoma: A Systematic Review

• Published in: Cancers Vol. 14; no. 5; p. 1201
• Main Authors: Indave Ruiz, Blanca Iciar, Armon, Subasri, Watanabe, Reiko, Uttley, Lesley, White, Valerie A., Lazar, Alexander J., Cree, Ian A.
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 25.02.2022; MDPI
• Subjects: Acquired immune deficiency syndrome; AIDS; Bias; Chromosome aberrations; Cytogenetics; HIV; Human immunodeficiency virus; Immunosuppression; Kaposi's sarcoma; Lesions; Mutation; Neoplasia; Systematic Review; Tumors; North America; Europe; Africa; HHV8; clonality; reactive; sarcoma; Kaposi; DNA

Background: It remains uncertain whether Kaposi sarcoma (KS) is a true neoplasm, in that it regresses after removal of the stimulus to growth (as HHV8) when immunosuppression is reduced. We aimed to summarize the available evidence on somatic mutations and clonality within KS to assess whether KS is...