Landscape of Mitochondria Genome and Clinical Outcomes in Stage 1 Lung Adenocarcinoma

• Published in: Cancers Vol. 12; no. 3; p. 755
• Main Authors: Raghav, Lovely, Chang, Ya-Hsuan, Hsu, Yi-Chiung, Li, Yu-Cheng, Chen, Chih-Yi, Yang, Tsung-Ying, Chen, Kun-Chieh, Hsu, Kuo-Hsuan, Tseng, Jeng-Sen, Chuang, Cheng-Yen, Lee, Mei-Hsuan, Wang, Chih-Liang, Chen, Huei-Wen, Yu, Sung-Liang, Su, Sheng-Fang, Yuan, Shin-Sheng, Chen, Jeremy J.W., Ho, Shinn-Ying, Li, Ker-Chau, Yang, Pan-Chyr, Chang, Gee-Chen, Chen, Hsuan-Yu
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 23.03.2020; MDPI
• Subjects: Adenocarcinoma; Age; Clinical outcomes; Genes; Genomes; Lung cancer; Mitochondria; Mutation; Next-generation sequencing; Patients; Precision medicine; Proteins; Risk factors; Tumors; somatic mutations; prognosis; mitochondria; lung adenocarcinoma; EGFR-activating mutations

Risk factors including genetic effects are still being investigated in lung adenocarcinoma (LUAD). Mitochondria play an important role in controlling imperative cellular parameters, and anomalies in mitochondrial function might be crucial for cancer development. The mitochondrial genomic aberrations...