Mouse ATF-2 Null Mutants Display Features of a Severe Type of Meconium Aspiration Syndrome

• Published in: The Journal of biological chemistry Vol. 274; no. 25; pp. 17813 - 17819
• Main Authors: Maekawa, T, Bernier, F, Sato, M, Nomura, S, Singh, M, Inoue, Y, Tokunaga, T, Imai, H, Yokoyama, M, Reimold, A, Glimcher, L H, Ishii, S
• Format: Journal Article
• Language: English
• Published: United States American Society for Biochemistry and Molecular Biology 18.06.1999
• Subjects: Activating Transcription Factor 2; Animals; Cyclic AMP Response Element-Binding Protein - genetics; Cyclic AMP Response Element-Binding Protein - metabolism; Disease Models, Animal; Gene Expression Regulation; Gene Targeting; Humans; Hypoxia - genetics; In Situ Hybridization; Infant, Newborn; Lung - pathology; Meconium Aspiration Syndrome - genetics; Meconium Aspiration Syndrome - pathology; Mice; Mice, Knockout; Mutation - genetics; Placenta - metabolism; Promoter Regions, Genetic; Receptors, Platelet-Derived Growth Factor - genetics; Respiratory Distress Syndrome, Newborn - genetics; Transcription Factors - genetics; Transcription Factors - metabolism

Mouse null mutants of transcription factor ATF-2 were generated by the gene targeting method. They died shortly after birth and displayed symptoms of severe respiratory distress with lungs filled with meconium. These features are similar to those of a severe type of human meconium aspiration syndrom...