Molecular basis of FAAH-OUT-associated human pain insensitivity

• Published in: Brain (London, England : 1878) Vol. 146; no. 9; pp. 3851 - 3865
• Main Authors: Mikaeili, Hajar, Habib, Abdella M, Yeung, Charlix Wai-Lok, Santana-Varela, Sonia, Luiz, Ana P, Panteleeva, Kseniia, Zuberi, Sana, Athanasiou-Fragkouli, Alkyoni, Houlden, Henry, Wood, John N, Okorokov, Andrei L, Cox, James J
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 01.09.2023
• Subjects: Original; pain; endocannabinoid system; pseudogene; anandamide; regulatory RNA

Abstract Chronic pain affects millions of people worldwide and new treatments are needed urgently. One way to identify novel analgesic strategies is to understand the biological dysfunctions that lead to human inherited pain insensitivity disorders. Here we report how the recently discovered brain a...