Scn1a haploinsufficiency in the prefrontal cortex leads to cognitive impairment and depressive phenotype - Riga, Maurizio S; Pérez-Fernández, Mercedes; Miquel-Rio, Lluis; Paz, Verónica; Campa, Leticia; Martínez-Losa, Magdalena; Esteban, Francisco J; Callado, Luis F; Meana, Javier; Artigas, Francesc; Bortolozzi, Analía; Álvarez-Dolado, Manuel (Brain (London, England : 1878), 2024)
Keywords: Animals; Cognitive Dysfunction - genetics; Cognitive Dysfunction - metabolism; Depressive Disorder, Major - genetics; Depressive Disorder, Major - metabolism; Female; Haploinsufficiency; Hippocampus - metabolism; Humans; Male; Mice; Mice, Inbred C57BL; NAV1.1 Voltage-Gated Sodium Channel - genetics; Original; Phenotype; Prefrontal Cortex - metabolism; Serotonin - metabolism; excitatory/inhibitory balance (E/I balance); Na; 1.1 channel; GABAergic interneurons; mayor depressive disorder; prefrontal cortex; Nav1.1 channel