Comparative Evaluation of Azadirachta indica (Neem) Chip and Soft Tissue Diode Lasers as a Supplement to Phase I Periodontal Therapy in Localized Chronic Moderate Periodontitis: A Randomized Controlled Clinical Trial

Introduction. The current trial aimed to assess and compare the efficacy of neem chip and diode laser as a local drug delivery (LDD) agent as a supplement to phase I periodontal therapy in treatment of localized chronic moderate periodontitis. Materials and Methodology. Fourteen systemically healthy...

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Published inInternational journal of dentistry Vol. 2022; pp. 1 - 6
Main Authors Ganvir, Minal N., Parwani, Simran R., Chaudhary, Dhanashree S., Parwani, Rajkumar, Dadlani, Himanshu, Vikey, Ashok K., Kawadkar, Kshipra P., Jaju, Nishita S., Armogida, Niccoló Giuseppe, Spagnuolo, Gianrico
Format Journal Article
LanguageEnglish
Published New York Hindawi 15.06.2022
Hindawi Limited
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Abstract Introduction. The current trial aimed to assess and compare the efficacy of neem chip and diode laser as a local drug delivery (LDD) agent as a supplement to phase I periodontal therapy in treatment of localized chronic moderate periodontitis. Materials and Methodology. Fourteen systemically healthy participants with 4–6 mm deep periodontal pockets at least in three quadrants (with no alveolar bony defect amenable to respective or regenerative osseous surgery, as seen in orthopantomograph) were selected for the trial. One week after phase I therapy, 10% absorbable chip of neem (commercially prepared by staff of a pharmacy college, Sheriguda, India) was placed in the periodontal pocket on one site, and soft tissue diode laser pocket sterilization was performed on the other site of the arch. Remaining one site was considered as a control. Parameters recorded clinically were plaque index (PI), papillary bleeding index (PBI), probing pocket depth (PPD), and relative attachment level (RAL) measured at baseline, 21st day, and one month postoperatively. Results. Statistically significant improvements were observed in all clinical parameters at one month as compared to baseline for both treatment groups. Conclusion. Neem chip supplemented with phase I therapy showed best improvement in clinical parameters followed by laser supplemented with phase I therapy in comparison to phase I therapy alone at one month follow-up. Clinical Significance. Neem chips are nature’s products, affordable without side effects, with a potential to be used as a local drug delivery agent in treating moderate chronic periodontitis.
AbstractList Introduction. The current trial aimed to assess and compare the efficacy of neem chip and diode laser as a local drug delivery (LDD) agent as a supplement to phase I periodontal therapy in treatment of localized chronic moderate periodontitis. Materials and Methodology. Fourteen systemically healthy participants with 4–6 mm deep periodontal pockets at least in three quadrants (with no alveolar bony defect amenable to respective or regenerative osseous surgery, as seen in orthopantomograph) were selected for the trial. One week after phase I therapy, 10% absorbable chip of neem (commercially prepared by staff of a pharmacy college, Sheriguda, India) was placed in the periodontal pocket on one site, and soft tissue diode laser pocket sterilization was performed on the other site of the arch. Remaining one site was considered as a control. Parameters recorded clinically were plaque index (PI), papillary bleeding index (PBI), probing pocket depth (PPD), and relative attachment level (RAL) measured at baseline, 21st day, and one month postoperatively. Results. Statistically significant improvements were observed in all clinical parameters at one month as compared to baseline for both treatment groups. Conclusion. Neem chip supplemented with phase I therapy showed best improvement in clinical parameters followed by laser supplemented with phase I therapy in comparison to phase I therapy alone at one month follow-up. Clinical Significance. Neem chips are nature’s products, affordable without side effects, with a potential to be used as a local drug delivery agent in treating moderate chronic periodontitis.
IntroductionThe current trial aimed to assess and compare the efficacy of neem chip and diode laser as a local drug delivery (LDD) agent as a supplement to phase I periodontal therapy in treatment of localized chronic moderate periodontitis. Materials and Methodology. Fourteen systemically healthy participants with 4-6 mm deep periodontal pockets at least in three quadrants (with no alveolar bony defect amenable to respective or regenerative osseous surgery, as seen in orthopantomograph) were selected for the trial. One week after phase I therapy, 10% absorbable chip of neem (commercially prepared by staff of a pharmacy college, Sheriguda, India) was placed in the periodontal pocket on one site, and soft tissue diode laser pocket sterilization was performed on the other site of the arch. Remaining one site was considered as a control. Parameters recorded clinically were plaque index (PI), papillary bleeding index (PBI), probing pocket depth (PPD), and relative attachment level (RAL) measured at baseline, 21st day, and one month postoperatively. ResultsStatistically significant improvements were observed in all clinical parameters at one month as compared to baseline for both treatment groups. ConclusionNeem chip supplemented with phase I therapy showed best improvement in clinical parameters followed by laser supplemented with phase I therapy in comparison to phase I therapy alone at one month follow-up. Clinical Significance. Neem chips are nature's products, affordable without side effects, with a potential to be used as a local drug delivery agent in treating moderate chronic periodontitis.
Author Parwani, Simran R.
Ganvir, Minal N.
Armogida, Niccoló Giuseppe
Parwani, Rajkumar
Kawadkar, Kshipra P.
Spagnuolo, Gianrico
Vikey, Ashok K.
Jaju, Nishita S.
Chaudhary, Dhanashree S.
Dadlani, Himanshu
AuthorAffiliation 6 Institute of Dentistry, I. M. Sechenov First Moscow State Medical University, Moscow 119435, Russia
1 Department of Periodontology, V.Y.W.S. Dental College and Hospital, Amravati, Maharashtra, India
5 Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples “Federico II”, Naples 80131, Italy
4 Department of Oral Pathology and Microbiology, Government College of Dentistry, Sardar Patel Marg, Indore-452 001, Madhya Pradesh, India
3 Kalka Dental College, Meerut 250016, India
2 Department of Oral Pathology and Microbiology, V.Y.W.S. Dental College and Hospital, Amravati, Maharashtra, India
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crossref_primary_10_3390_app14052009
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Snippet Introduction. The current trial aimed to assess and compare the efficacy of neem chip and diode laser as a local drug delivery (LDD) agent as a supplement to...
IntroductionThe current trial aimed to assess and compare the efficacy of neem chip and diode laser as a local drug delivery (LDD) agent as a supplement to...
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SubjectTerms Alveoli
Antibiotics
Cellulose
Clinical trials
Disease
Drug delivery
Gum disease
Infections
Lasers
Microorganisms
Natural products
Neem
Periodontitis
Plaque index
Polyethylene glycol
Polymers
Statistical analysis
Sterilization
Teeth
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Title Comparative Evaluation of Azadirachta indica (Neem) Chip and Soft Tissue Diode Lasers as a Supplement to Phase I Periodontal Therapy in Localized Chronic Moderate Periodontitis: A Randomized Controlled Clinical Trial
URI https://dx.doi.org/10.1155/2022/6109040
https://www.proquest.com/docview/2680913810
https://search.proquest.com/docview/2681440632
https://pubmed.ncbi.nlm.nih.gov/PMC9217592
https://doaj.org/article/9b92519e3f4240c6a44756c9a216a994
Volume 2022
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