GABA and Glx levels in cortico-subcortical networks predict catecholaminergic effects on response inhibition

• Published in: Journal of psychopharmacology (Oxford) Vol. 39; no. 8; pp. 769 - 781
• Main Authors: Koyun, Anna Helin, Werner, Annett, Kuntke, Paul, Roessner, Veit, Beste, Christian, Stock, Ann-Kathrin
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.08.2025
• Subjects: Adult; Catecholamines - metabolism; Central Nervous System Stimulants - administration & dosage; Central Nervous System Stimulants - pharmacology; Corpus Striatum - drug effects; Corpus Striatum - metabolism; Dose-Response Relationship, Drug; Female; gamma-Aminobutyric Acid - metabolism; Glutamic Acid - metabolism; Glutamine - metabolism; Gyrus Cinguli - drug effects; Gyrus Cinguli - metabolism; Humans; Male; Methylphenidate - administration & dosage; Methylphenidate - pharmacology; Motor Cortex - drug effects; Motor Cortex - metabolism; Proton Magnetic Resonance Spectroscopy; Young Adult; GABA; 1H-MRS; Glx; response inhibition; dopamine and norepinephrine

Background: Cortico-subcortical networks play a fundamental role in cognitive control. Within these circuits, neurotransmitters such as gamma-aminobutyric acid (GABA), glutamate, and catecholamines crucially modulate response control and (motor) response inhibition. Despite the evident interrelation...