Molecular Targeting of HuR Oncoprotein Suppresses MITF and Induces Apoptosis in Melanoma Cells

• Published in: Cancers Vol. 13; no. 2; p. 166
• Main Authors: Ahmed, Rebaz, Muralidharan, Ranganayaki, Srivastava, Akhil, Johnston, Sarah E, Zhao, Yan D, Ekmekcioglu, Suhendan, Munshi, Anupama, Ramesh, Rajagopal
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 06.01.2021; MDPI
• Subjects: Antitumor activity; Apoptosis; Cancer therapies; Cell cycle; Cell growth; Cell migration; Cell viability; Cytotoxicity; Drug resistance; Experiments; Gene silencing; HuR protein; Immunotherapy; Kinases; Lipids; MEK inhibitors; Melanocytes; Melanoma; Metastases; Metastasis; Microphthalmia-associated transcription factor; Nanoparticles; Oncoproteins; Patients; Proteins; Raf protein; siRNA; Skin cancer; Western blotting; United States > US; metastases; targeted therapy; nanoparticles; HuR; melanoma; MITF; siRNA

Treatment of metastatic melanoma possesses challenges due to drug resistance and metastases. Recent advances in targeted therapy and immunotherapy have shown clinical benefits in melanoma patients with increased survival. However, a subset of patients who initially respond to targeted therapy relaps...