Detection of multiple drug-resistance-associated pol mutations in cervicovaginal secretions from women largely treated with antiretroviral agents
The prolonged use of antiretroviral agents almost invariably leads to the emergence of HIV-1-resistant variants [1]. It has previously been demonstrated that HIV-1 variants resistant to zidovudine are shed in semen and can be transmitted through sexual contact. Viral variants carrying mutations corr...
Saved in:
Published in | AIDS (London) Vol. 13; no. 8; pp. 992 - 994 |
---|---|
Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Hagerstown, MD
Lippincott Williams & Wilkins
28.05.1999
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | The prolonged use of antiretroviral agents almost invariably leads to the emergence of HIV-1-resistant variants [1]. It has previously been demonstrated that HIV-1 variants resistant to zidovudine are shed in semen and can be transmitted through sexual contact. Viral variants carrying mutations correlated to resistance to several reverse transcriptase inhibitors were also detected in semen [2,3]. In addition, one case of male-to-male sexual transmission of an HIV-1 variant with multiple mutations conferring resistance to both reverse transcriptase and protease inhibitors has been reported [4]. Although mutant HIVs have been detected in seminal fluid, to our knowledge, the presence of HIV variants with multiple drug-resistant mutations in the female genital tract has never been investigated. The aim of this study was to investigate the presence of HIV-1 variants with multiple mutations associated with resistance to both reverse transcriptase and protease inhibitors in the genital secretions of women treated with antiretroviral drugs. |
---|---|
AbstractList | The prolonged use of antiretroviral agents almost invariably leads to the emergence of HIV-1-resistant variants [1]. It has previously been demonstrated that HIV-1 variants resistant to zidovudine are shed in semen and can be transmitted through sexual contact. Viral variants carrying mutations correlated to resistance to several reverse transcriptase inhibitors were also detected in semen [2,3]. In addition, one case of male-to-male sexual transmission of an HIV-1 variant with multiple mutations conferring resistance to both reverse transcriptase and protease inhibitors has been reported [4]. Although mutant HIVs have been detected in seminal fluid, to our knowledge, the presence of HIV variants with multiple drug-resistant mutations in the female genital tract has never been investigated. The aim of this study was to investigate the presence of HIV-1 variants with multiple mutations associated with resistance to both reverse transcriptase and protease inhibitors in the genital secretions of women treated with antiretroviral drugs. |
Author | FIORE, J. R PASTORE, G MONNO, L DI STEFANO, M LEPERA, A ANGARANO, G |
Author_xml | – sequence: 1 givenname: M surname: DI STEFANO fullname: DI STEFANO, M organization: Clinic of Infectious Diseases, 70124 Bari, Italy – sequence: 2 givenname: J. R surname: FIORE fullname: FIORE, J. R organization: Clinic of Infectious Diseases, 70124 Bari, Italy – sequence: 3 givenname: L surname: MONNO fullname: MONNO, L organization: Clinic of Infectious Diseases, 70124 Bari, Italy – sequence: 4 givenname: A surname: LEPERA fullname: LEPERA, A organization: Obstetric and Gynecological Clinic, University of Bari, 70124 Bari, Italy – sequence: 5 givenname: G surname: PASTORE fullname: PASTORE, G organization: Clinic of Infectious Diseases, 70124 Bari, Italy – sequence: 6 givenname: G surname: ANGARANO fullname: ANGARANO, G organization: Clinic of Infectious Diseases, 70124 Bari, Italy |
BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1798813$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/10371183$$D View this record in MEDLINE/PubMed |
BookMark | eNqFkctuEzEUhi1URNPCKyAvELspvmR8WaJyKVIlNrAenXiOg5HHDraTqo_BG-M24bLDG0s-338s_d8FOUs5ISGUsyvOrH7D-hFMsoFba9koDBv6CzdPyIqvtRzGUfMzsmJC2cFKzc7JRa3fOzIyY56Rc86k5tzIFfn5Dhu6FnKi2dNlH1vYRaRz2W-HgjXUBsnhALVmF6DhTHc5dq7BQ6bSkKjDcgguH2AbEkRa0RU8Dn3JC73LCyYaoWwx3tNW8HHLXWjfKKQWOlvyIZSehC2mVp-Tpx5ixRen-5J8_fD-y_XNcPv546frt7eDWwveBjOvvbZqtELPQjm5Acms0cA57004JkAYITd9omH2vSLhlVKjhz7xSjt5SV4f9-5K_rHH2qYlVIcxQsK8r5OyRqje6X9BroUyas06aI6gK7nWgn7albBAuZ84mx68Tb-9TX-8TY_eevTl6Y_9ZsH5n-BRVAdenQCoDqIvXUuofzltjeFS_gJtvKUS |
CitedBy_id | crossref_primary_10_1128_AAC_47_1_238_243_2003 crossref_primary_10_1097_00126334_200309010_00005 crossref_primary_10_1002_1099_1654_200007_08_10_4_231__AID_RMV290_3_0_CO_2_P crossref_primary_10_1128_AAC_48_2_632_634_2004 |
Cites_doi | 10.1056/NEJM199807303390504 10.1097/00002030-199815000-00003 10.1128/JVI.70.3.2038-2043.1996 10.1128/JVI.66.9.5627-5630.1992 10.1126/science.2467383 10.1002/jmv.1890320411 10.1038/nm0796-753 10.1097/00002030-199303000-00020 10.1128/CDLI.2.1.57-61.1995 |
ContentType | Journal Article |
Copyright | 1999 INIST-CNRS |
Copyright_xml | – notice: 1999 INIST-CNRS |
DBID | IQODW CGR CUY CVF ECM EIF NPM AAYXX CITATION 7T7 7U9 8FD C1K FR3 H94 P64 7X8 |
DOI | 10.1097/00002030-199905280-00018 |
DatabaseName | Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef Industrial and Applied Microbiology Abstracts (Microbiology A) Virology and AIDS Abstracts Technology Research Database Environmental Sciences and Pollution Management Engineering Research Database AIDS and Cancer Research Abstracts Biotechnology and BioEngineering Abstracts MEDLINE - Academic |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef Virology and AIDS Abstracts Technology Research Database AIDS and Cancer Research Abstracts Engineering Research Database Industrial and Applied Microbiology Abstracts (Microbiology A) Biotechnology and BioEngineering Abstracts Environmental Sciences and Pollution Management MEDLINE - Academic |
DatabaseTitleList | Virology and AIDS Abstracts |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine |
EISSN | 1473-5571 |
EndPage | 994 |
ExternalDocumentID | 10_1097_00002030_199905280_00018 10371183 1798813 |
Genre | Letter Research Support, Non-U.S. Gov't |
GroupedDBID | --- .GJ .XZ .Z2 01R 08R 0R~ 1CY 1J1 23M 2WC 354 40H 4Q1 4Q2 4Q3 53G 5GY 5RE 5VS 71W 77Y 7O~ 85S 8L- AAAXR AAGIX AAHPQ AAJCS AAMOA AAMTA AAPBV AAQKA AARTV AASOK AASXQ AAXQO ABASU ABBUW ABDIG ABIVO ABXVJ ABZAD ACCJW ACDDN ACEWG ACGFS ACILI ACOAL ACWDW ACWRI ACXNZ ADBBV ADFPA ADGGA ADNKB AE3 AE6 AEBDS AEETU AENEX AFDTB AFFNX AFUWQ AGINI AHOMT AHRYX AHVBC AIJEX AJIOK AJNWD AJNYG AKALU AKULP ALMA_UNASSIGNED_HOLDINGS ALMTX AMJPA AMKUR AMNEI AOHHW AWKKM BAWUL BOYCO BQLVK BS7 BYPQX C45 CAG COF CS3 DIK DIWNM DUNZO E.X E3Z EBS EEVPB EJD EX3 F2K F2L F2M F2N F5P FCALG FL- FW0 GNXGY GQDEL H0~ HZ~ IKREB IKYAY IN~ IPNFZ IQODW JF9 JG8 JK3 JK8 K8S KD2 KMI KQ8 L-C L7B N4W N9A N~7 N~B N~M O9- OAG OAH OBH OCUKA ODA ODMTH OHH OHYEH OJAPA OK1 OL1 OLB OLG OLH OLU OLV OLW OLY OLZ OPUJH OPX ORVUJ OUVQU OVD OVDNE OVIDH OVLEI OVOZU OWU OWV OWW OWX OWY OWZ OXXIT P-K P2P R58 RIG RLZ S4R S4S SJN T8P TEORI TR2 TSPGW UAP V2I VVN W3M WOQ WOW X3V X3W XJT XXN XYM YFH ZGI ZXP ZZMQN AAAAV AAIQE AAUEB ABJNI ADHPY AFEXH AHQNM AINUH AJZMW CGR CUY CVF ECM EIF NPM AASCR AAYXX ABVCZ ACXJB AFSOK CITATION ERAAH HLJTE 7T7 7U9 8FD C1K FR3 H94 P64 7X8 |
ID | FETCH-LOGICAL-c421t-8d4f7965927d26c3ba30987a111001c02a2823b6c37adf5282f6665fa02af67c3 |
ISSN | 0269-9370 |
IngestDate | Sat Aug 17 00:31:58 EDT 2024 Fri Aug 16 05:01:06 EDT 2024 Fri Aug 23 00:26:28 EDT 2024 Sat Sep 28 08:37:36 EDT 2024 Sun Oct 29 17:08:09 EDT 2023 |
IsDoiOpenAccess | false |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 8 |
Keywords | Human Immunopathology Secretion Genetic variant AIDS Vaginal fluid Immune deficiency Infection Chemotherapy Microbiological investigation Treatment Viral disease Multiple resistance Female genital system Antiviral Female Mutation Negative therapeutic reaction |
Language | English |
License | CC BY 4.0 |
LinkModel | OpenURL |
MergedId | FETCHMERGED-LOGICAL-c421t-8d4f7965927d26c3ba30987a111001c02a2823b6c37adf5282f6665fa02af67c3 |
Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 SourceType-Other Sources-1 content type line 63 ObjectType-Correspondence-1 |
OpenAccessLink | https://doi.org/10.1097/00002030-199905280-00018 |
PMID | 10371183 |
PQID | 17268640 |
PQPubID | 23462 |
PageCount | 3 |
ParticipantIDs | proquest_miscellaneous_69826018 proquest_miscellaneous_17268640 crossref_primary_10_1097_00002030_199905280_00018 pubmed_primary_10371183 pascalfrancis_primary_1798813 |
PublicationCentury | 1900 |
PublicationDate | 1999-05-28 |
PublicationDateYYYYMMDD | 1999-05-28 |
PublicationDate_xml | – month: 05 year: 1999 text: 1999-05-28 day: 28 |
PublicationDecade | 1990 |
PublicationPlace | Hagerstown, MD |
PublicationPlace_xml | – name: Hagerstown, MD – name: England |
PublicationTitle | AIDS (London) |
PublicationTitleAlternate | AIDS |
PublicationYear | 1999 |
Publisher | Lippincott Williams & Wilkins |
Publisher_xml | – name: Lippincott Williams & Wilkins |
References | Wainberg (R2-18-20110409) 1993; 7 Hecht (R4-18-20110409) 1998; 339 Kozal (R8-18-20110409) 1996; 2 Batisse (R13-18-20110409) 1998; 12 Larder (R1-18-20110409) 1989; 243 Belec (R5-18-20110409) 1995; 2 Fiore (R6-18-20110409) 1990; 32 Albert (R12-18-20110409) 1992; 66 Lech (R9-18-20110409) 1996; 70 Eron (R3-18-20110409) 1998; 12 |
References_xml | – volume: 339 start-page: 307 year: 1998 ident: R4-18-20110409 publication-title: N Engl J Med doi: 10.1056/NEJM199807303390504 contributor: fullname: Hecht – volume: 12 start-page: 824 year: 1998 ident: R13-18-20110409 publication-title: AIDS contributor: fullname: Batisse – volume: 12 start-page: F181 year: 1998 ident: R3-18-20110409 publication-title: AIDS doi: 10.1097/00002030-199815000-00003 contributor: fullname: Eron – volume: 70 start-page: 2038 year: 1996 ident: R9-18-20110409 publication-title: J Virol doi: 10.1128/JVI.70.3.2038-2043.1996 contributor: fullname: Lech – volume: 66 start-page: 5627 year: 1992 ident: R12-18-20110409 publication-title: J Virol doi: 10.1128/JVI.66.9.5627-5630.1992 contributor: fullname: Albert – volume: 243 start-page: 1731 year: 1989 ident: R1-18-20110409 publication-title: Science doi: 10.1126/science.2467383 contributor: fullname: Larder – volume: 32 start-page: 252 year: 1990 ident: R6-18-20110409 publication-title: J Med Virol doi: 10.1002/jmv.1890320411 contributor: fullname: Fiore – volume: 2 start-page: 753 year: 1996 ident: R8-18-20110409 publication-title: Nature Med doi: 10.1038/nm0796-753 contributor: fullname: Kozal – volume: 7 start-page: 433 year: 1993 ident: R2-18-20110409 publication-title: AIDS doi: 10.1097/00002030-199303000-00020 contributor: fullname: Wainberg – volume: 2 start-page: 57 year: 1995 ident: R5-18-20110409 publication-title: Clin Diagn Lab Immunol doi: 10.1128/CDLI.2.1.57-61.1995 contributor: fullname: Belec |
SSID | ssj0005088 |
Score | 1.6596047 |
Snippet | The prolonged use of antiretroviral agents almost invariably leads to the emergence of HIV-1-resistant variants [1]. It has previously been demonstrated that... |
SourceID | proquest crossref pubmed pascalfrancis |
SourceType | Aggregation Database Index Database |
StartPage | 992 |
SubjectTerms | AIDS/HIV Anti-HIV Agents - pharmacology Anti-HIV Agents - therapeutic use Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Biological and medical sciences Cervix Uteri - virology Drug Resistance, Microbial - genetics Drug Resistance, Multiple - genetics Drug Therapy, Combination Female Genes, pol HIV Infections - drug therapy HIV Infections - virology HIV Protease - genetics HIV Reverse Transcriptase - genetics HIV-1 - drug effects HIV-1 - genetics Human immunodeficiency virus 1 Humans Medical sciences Mutation Pharmacology. Drug treatments Retrovirus Vagina - virology |
Title | Detection of multiple drug-resistance-associated pol mutations in cervicovaginal secretions from women largely treated with antiretroviral agents |
URI | https://www.ncbi.nlm.nih.gov/pubmed/10371183 https://search.proquest.com/docview/17268640 https://search.proquest.com/docview/69826018 |
Volume | 13 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1bi9NAFB7qCiKIeF2rrs6Db0tkMpPbPIrdsrt21wdb6FuYJDNLoSSlTQX1V_iPPXPJDbd4eQklmSYh35eTc2a-cw5C7wiReSyU8FRBlBfwLPO4YNKDjytnJE9EYnKrrq6j80VwuQyXo9GPfnZJnb3Pv9-aV_I_qMI-wFVnyf4Dsu1JYQf8BnxhCwjD9q8wnsha5o3L10oDi-3-xoMoWnuGAKknHALgWm6qNYyrOwF5bkxF9VXY7lg77UTagybvxNRnOF1rtfj6mxWlN3J1QASsZa1nJHSOv7hpikK1NW0vJl_6DUPaGYfJSmvLlDBNv7vZ2OnKSX4vT3tS4NKOaqeoZ3Ijt6KbhC1cBh_Xa-20Z2Mh6uMeeEVkYIRZj2xJz6Jy2yrPfZy57Yj8m9239YSJXVglWj3DSUgTkzTv7Pug1Pb153S6mM3S-dlyfgfdpTEPdeQ-ufjU6YOIaVra3q2TgTUVP2-7zsC3ebARO3jNlO2PcjiAMY7M_BF66CIQ_MHS6TEayfIJunflNBZP0c-WVbhSuGEVPswqDKzCLavwqsRDVuGOVVizChtWYccq7FiFNavwkFXYsuoZWkzP5h_PPde4w8sD6tdeUgQq1pUqaVzQKGeZYIQnsfB1fUI_J1RAoM8yOBKLQsHzowqi6FAJOKKiOGfP0VFZlfIFwszPQqFoCGdUgWQi08OVgrGcMBaEY-Q3jzzd2PosaU9XYWBKW5iM1CIZo5MBNt0fdfE-n43R2warFIytXkETpaz2OxhAoyQKyOEREU90kT64xrEFuXdXLIZonr3849lfofvde_MaHdXbvTwB17fO3hiK_gKPv7Fe |
link.rule.ids | 315,786,790,27957,27958 |
linkProvider | Flying Publisher |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Detection+of+multiple+drug-resistance-associated+pol+mutations+in+cervicovaginal+secretions+from+women+largely+treated+with+antiretroviral+agents&rft.jtitle=AIDS+%28London%29&rft.au=Di+Stefano%2C+M&rft.au=Fiore%2C+J+R&rft.au=Monno%2C+L&rft.au=Lepera%2C+A&rft.date=1999-05-28&rft.issn=0269-9370&rft.volume=13&rft.issue=8&rft.spage=992&rft.epage=994&rft_id=info:doi/10.1097%2F00002030-199905280-00018&rft.externalDBID=NO_FULL_TEXT |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0269-9370&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0269-9370&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0269-9370&client=summon |