BCL6 alternative breakpoint region break and homozygous deletion of 17q24 in the nodular lymphocyte predominance type of Hodgkin's lymphoma–derived cell line DEV

• Published in: Human pathology Vol. 37; no. 6; pp. 675 - 683
• Main Authors: Atayar, Çiğdem, Kok, Klaas, Kluiver, Joost, Bosga, Anneke, van den Berg, Eva, van der Vlies, Pieter, Blokzijl, Tjasso, Harms, Geert, Davelaar, Inge, Sikkema-Raddatz, Birgit, Martin-Subero, Josẻ Ignacio, Siebert, Reiner, Poppema, Sibrand, van den Berg, Anke
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.06.2006; Elsevier; Elsevier Limited
• Subjects: 17q24 deletion; BCL6 ABR breakpoint; Biological and medical sciences; Cell Line, Tumor; Chromosome Breakage; Chromosome Deletion; Chromosome Mapping; Chromosomes, Human, Pair 17; Cloning; Cytogenetic Analysis; DEV; DNA-Binding Proteins - genetics; Genetic Markers; Hematologic and hematopoietic diseases; Hodgkin Disease - genetics; Hodgkin Disease - pathology; Hodgkin's lymphoma; Homozygote; Humans; Immunohistochemistry; Immunophenotyping; In Situ Hybridization, Fluorescence; Investigative techniques, diagnostic techniques (general aspects); Kinases; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Lymphocytes; Lymphocytes - physiology; Male; Medical sciences; Microsatellite Repeats; Middle Aged; NLPHL; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques; Proto-Oncogene Proteins c-bcl-6; Signal transduction; Germany; NLPHL; 17q24 deletion; BCL6 ABR breakpoint; DEV; Hodgkin's lymphoma; Breakpoint; Break; Hodgkin disease; Malignant hemopathy; Homozygosity; Anatomic pathology; Cell line; Chromosome E17; Lymphoproliferative syndrome; C-Onc gene; Established cell line; Deletion; Lymphocyte-predominant Hodgkin lymphoma; Tumor cell; Protooncogene

DEV is the only cell line derived from nodular lymphocyte predominance type of Hodgkin's lymphoma (NLPHL); however, a comprehensive report about the genetic and immunophenotypic profile of this unique cell line is lacking. We analyzed DEV with respect to immunophenotype and genetic aberrations....