A randomized comparison of thalamic stimulation and lesion on self-paced finger movement in essential tremor

• Published in: Neuroscience letters Vol. 462; no. 2; pp. 166 - 170
• Main Authors: Anderson, Valerie C., Burchiel, Kim J., Hart, Melanie J., Berk, Caglar, Lou, Jau-Shin
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 22.09.2009; Elsevier
• Subjects: Aged; Biological and medical sciences; Deep Brain Stimulation; Essential tremor; Essential Tremor - physiopathology; Essential Tremor - therapy; Female; Fingers - innervation; Fundamental and applied biological sciences. Psychology; Humans; Male; Middle Aged; Pilot Projects; Psychomotor Performance; Stereotaxic Techniques; Thalamotomy; Thalamus - physiopathology; Thalamus - surgery; Timing; Vertebrates: nervous system and sense organs; Timing; Deep brain stimulation; Essential tremor; Thalamotomy; Central nervous system; Finger; Thalamus; Lesion; Encephalon

Deep brain stimulation (DBS) and ablation (thalamotomy) of the motor thalamus reduce tremor and improve function of the contralateral hand in patients with essential tremor (ET). Neuroimaging and electrophysiological evidence suggest that unlike a focal lesion, high frequency stimulation affects wid...