Incorporation of bromodeoxyuridine in glutathione S-transferase-positive hepatocytes during rat multistage hepatocarcinogenesis

• Published in: Carcinogenesis (New York) Vol. 15; no. 9; p. 1939
• Main Authors: Dragan, Y P, Hully, J, Crow, R, Mass, M, Pitot, H C
• Format: Journal Article
• Language: English
• Published: England 01.09.1994
• Subjects: Animals; Bromodeoxyuridine - metabolism; Cell Division - drug effects; Cocarcinogenesis; Diethylnitrosamine; Glutathione Transferase - metabolism; Liver - cytology; Liver - enzymology; Liver - metabolism; Liver Neoplasms, Experimental - chemically induced; Liver Neoplasms, Experimental - enzymology; Liver Neoplasms, Experimental - pathology; Male; Models, Biological; Phenobarbital - toxicity; Rats; Rats, Inbred F344

Cell proliferation is pivotal to all stages of the carcinogenesis process and is one of the primary characteristics of the promotion stage of cancer development. Both a two-stage model of initiation and promotion for analysis of early preneoplasia and a three-stage initiation-promotion-progression m...