Whole Genome Sequencing of Spontaneously Occurring Rat Natural Killer Large Granular Lymphocyte Leukemia Identifies JAK1 Somatic Activating Mutation

• Published in: Cancers Vol. 12; no. 1; p. 126
• Main Authors: Wang, T Tiffany, Yang, Jun, Dighe, Shubha, Schmachtenberg, Matthew W, Leigh, Nathan T, Farber, Emily, Onengut-Gumuscu, Suna, Feith, David J, Ratan, Aakrosh, Loughran, Jr, Thomas P, Olson, Thomas L
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 03.01.2020; MDPI
• Subjects: Adaptation; Anemia; Cytokines; Cytotoxicity; Disease; Genes; Genomes; Hematology; Janus kinase; Kinases; Leukemia; Lymphocytes; Mutation; Phosphorylation; Proteins; Spleen; Stat1 protein; Stat3 protein; Stat5 protein; Transplantation; Whole genome sequencing; leukemia; mutation; NK cells; RNK-16; JAK/STAT; activation; F344

Large granular lymphocyte (LGL) leukemia arises spontaneously in elderly Fischer (F344) rats. This rodent model has been shown to emulate many aspects of the natural killer (NK) variant of human LGL leukemia. Previous transplantation of leukemic material into young F344 rats resulted in several stra...