Telomere and Centromere Staining Followed by M-FISH Improves Diagnosis of Chromosomal Instability and Its Clinical Utility

• Published in: Genes Vol. 11; no. 5; p. 475
• Main Authors: M'kacher, Radhia, Colicchio, Bruno, Borie, Claire, Junker, Steffen, Marquet, Valentine, Heidingsfelder, Leonhard, Soehnlen, Kevin, Najar, Wala, Hempel, William M, Oudrhiri, Noufissa, Wilhelm-Murer, Nadège, Miguet, Marguerite, Arnoux, Micheline, Ferrapie, Catherine, Kerbrat, Wendy, Plesch, Andreas, Dieterlen, Alain, Girinsky, Theodore, Voisin, Philippe, Deschenes, Georges, Tabet, Anne-Claude, Yardin, Catherine, Bennaceur-Griscelli, Annelise, Fenech, Michael, Carde, Patrice, Jeandidier, Eric
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI 27.04.2020
• Subjects: Cancer; Centromere - genetics; Chromosomal Instability - genetics; Chromosome Aberrations; Cytogenetic Analysis - methods; Female; Genetics; Human genetics; Humans; In Situ Hybridization, Fluorescence - methods; Life Sciences; Lymphocytes - pathology; Male; Metaphase - genetics; Middle Aged; Neoplasms - classification; Neoplasms - diagnosis; Neoplasms - genetics; Neoplasms - pathology; Telomere - genetics; centromere; cancer; dicentric chromosome; genetic syndrome; chromosomal instability; telomere

Dicentric chromosomes are a relevant marker of chromosomal instability. Their appearance is associated with telomere dysfunction, leading to cancer progression and a poor clinical outcome. Here, we present Telomere and Centromere staining followed by M-FISH (TC+M-FISH) for improved detection of telo...