Endotoxin neutralization by an O-antigen specific monoclonal antibody: A potential novel therapeutic approach against Klebsiella pneumoniae ST258

• Published in: Virulence Vol. 8; no. 7; pp. 1203 - 1215
• Main Authors: Szijártó, Valéria, Guachalla, Luis M., Hartl, Katharina, Varga, Cecília, Badarau, Adriana, Mirkina, Irina, Visram, Zehra C., Stulik, Lukas, Power, Christine A., Nagy, Eszter, Nagy, Gábor
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 03.10.2017
• Subjects: Animals; Antibodies, Bacterial - immunology; Antibodies, Bacterial - therapeutic use; Antibodies, Monoclonal - immunology; Antibodies, Monoclonal - therapeutic use; carbapenem-resistant Klebsiella; endotoxin neutralization; Endotoxins - immunology; Female; Humans; Immunization, Passive; Klebsiella Infections - drug therapy; Klebsiella Infections - immunology; Klebsiella Infections - microbiology; Klebsiella pneumoniae - drug effects; Klebsiella pneumoniae - genetics; Klebsiella pneumoniae - immunology; Klebsiella pneumoniae ST258; Male; Mice; Mice, Inbred BALB C; monoclonal antibody; Neutralization Tests; O Antigens - immunology; protective efficacy; Rabbits; Rats; Rats, Sprague-Dawley; Research Paper; carbapenem-resistant Klebsiella; endotoxin neutralization; protective efficacy; monoclonal antibody; Klebsiella pneumoniae ST258

Klebsiella pneumoniae ST258 is a globally distributed multi-drug resistant pathogen responsible for severe invasive infections. In this study, the different virulence potential of K. pneumoniae ST258 isolates in endotoxin susceptible versus resistant animal models was shown. Furthermore, ST258 clini...