The emergence of cytomegalovirus resistance to ganciclovir therapy in kidney transplant recipients

• Published in: International immunopharmacology Vol. 6; no. 13; pp. 2031 - 2037
• Main Authors: Nogueira, Eliana, Ozaki, Kikumi S., Tomiyama, Helena, Granato, Celso F.H., Camara, Niels O.S., Silva, Alvaro Pacheco e
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Amsterdam Elsevier B.V 20.12.2006; Elsevier
• Subjects: Adolescent; Adult; Amino Acid Substitution - genetics; Antiviral Agents - pharmacology; Antiviral Agents - therapeutic use; Biological and medical sciences; CMV; Cytomegalovirus; Cytomegalovirus - genetics; Cytomegalovirus - immunology; Cytomegalovirus - isolation & purification; Cytomegalovirus Infections - drug therapy; Cytomegalovirus Infections - etiology; Cytomegalovirus Infections - virology; Drug Resistance, Viral - genetics; Female; Ganciclovir; Ganciclovir - pharmacology; Ganciclovir - therapeutic use; Genotype; Graft Rejection - prevention & control; Humans; Immunosuppression - adverse effects; Immunosuppressive Agents - adverse effects; Immunosuppressive Agents - therapeutic use; Kidney transplant; Kidney Transplantation - immunology; Male; Medical sciences; Middle Aged; Pancreas Transplantation - immunology; Pharmacology. Drug treatments; Phosphotransferases (Alcohol Group Acceptor) - genetics; Resistance; UL97; Viral Envelope Proteins - genetics; Viral Load; Resistance; Ganciclovir; UL97; Kidney transplant; CMV; Cytomegalovirus; Acyclic nucleoside; Purine nucleoside; Herpesviridae; Transplantation; Homotransplantation; Betaherpesvirinae; Kidney; Infection; Virus; Treatment; Urinary system; Surgery; Viral disease; Nucleoside analog; Graft; Antiviral

Transplant recipients that have not been previously exposed to the cytomegalovirus (CMV) are highly susceptible to viral diseases while under immunosuppression therapy. CMV disease requires prolonged therapy, facilitating the emergence of resistant strains. Persistence of positive antigenemia repres...