p21 produces a bioactive secretome that places stressed cells under immunosurveillance

• Published in: Science (American Association for the Advancement of Science) Vol. 374; no. 6567; p. eabb3420
• Main Authors: Sturmlechner, Ines, Zhang, Cheng, Sine, Chance C., van Deursen, Erik-Jan, Jeganathan, Karthik B., Hamada, Naomi, Grasic, Jan, Friedman, David, Stutchman, Jeremy T., Can, Ismail, Hamada, Masakazu, Lim, Do Young, Lee, Jeong-Heon, Ordog, Tamas, Laberge, Remi-Martin, Shapiro, Virginia, Baker, Darren J., Li, Hu, van Deursen, Jan M.
• Format: Journal Article
• Language: English
• Published: United States The American Association for the Advancement of Science 29.10.2021
• Subjects: Age related diseases; Aging; Animals; Biological activity; Cancer; Cell cycle; Cell Cycle Checkpoints; Cell death; Cell fate; Cell Line; Cell surface; Cellular Senescence; Chemokines; Chemokines, CXC - metabolism; Cyclin-dependent kinase; Cyclin-Dependent Kinase Inhibitor p16 - genetics; Cyclin-Dependent Kinase Inhibitor p16 - metabolism; Cyclin-dependent kinase inhibitor p21; Cyclin-Dependent Kinase Inhibitor p21 - genetics; Cyclin-Dependent Kinase Inhibitor p21 - metabolism; Cyclin-dependent kinase inhibitor p27; Cyclin-dependent kinases; Cytokines; Cytotoxicity; Damage detection; Damage prevention; DNA damage; Enhancers; Enzyme inhibitors; Genes; Genes, ras; Genetic screening; Genotype & phenotype; GTP-binding protein; Hepatocytes - immunology; Hepatocytes - metabolism; Humans; Immune clearance; Immune response; Immune system; Immunologic Surveillance; Immunosurveillance; Impact damage; Kinases; Liver; Logical Thinking; Lymphocytes; Lymphocytes T; Macrophages; Macrophages - immunology; Macrophages - metabolism; Mice; Mice, Transgenic; Normalizing; Phenotypes; Proteins; Proto-Oncogene Proteins p21(ras) - metabolism; Recognition; Repair; Retina; Retinoblastoma; Retinoblastoma Protein - metabolism; Senescence; Stress, Physiological; Stresses; T-Lymphocytes, Cytotoxic - immunology; Transcription factors; Transcription, Genetic; Tumor suppression; Tumors

Senescent cells promote their own recognition and removal through the immune system by generating a bioactive secretome called the senescence-associated secretory phenotype (SASP). Sturmlechner et al . report that the cell cycle regulator p21 directs an early form of the SASP, which they call the p2...