p21 produces a bioactive secretome that places stressed cells under immunosurveillance - Sturmlechner, Ines; Zhang, Cheng; Sine, Chance C.; van Deursen, Erik-Jan; Jeganathan, Karthik B.; Hamada, Naomi; Grasic, Jan; Friedman, David; Stutchman, Jeremy T.; Can, Ismail; Hamada, Masakazu; Lim, Do Young; et al. (Science (American Association for the Advancement of Science), 2021)
Keywords: Age related diseases; Aging; Animals; Biological activity; Cancer; Cell cycle; Cell Cycle Checkpoints; Cell death; Cell fate; Cell Line; Cell surface; Cellular Senescence; Chemokines; Chemokines, CXC - metabolism; Cyclin-dependent kinase; Cyclin-Dependent Kinase Inhibitor p16 - genetics; Cyclin-Dependent Kinase Inhibitor p16 - metabolism; Cyclin-dependent kinase inhibitor p21; Cyclin-Dependent Kinase Inhibitor p21 - genetics; Cyclin-Dependent Kinase Inhibitor p21 - metabolism; Cyclin-dependent kinase inhibitor p27; Cyclin-dependent kinases; Cytokines; Cytotoxicity; Damage detection; Damage prevention; DNA damage; Enhancers; Enzyme inhibitors; Genes; Genes, ras; Genetic screening; Genotype & phenotype; GTP-binding protein; Hepatocytes - immunology; Hepatocytes - metabolism; Humans; Immune clearance; Immune response; Immune system; Immunologic Surveillance; Immunosurveillance; Impact damage; Kinases; Liver; Logical Thinking; Lymphocytes; Lymphocytes T; Macrophages; Macrophages - immunology; Macrophages - metabolism; Mice; Mice, Transgenic; Normalizing; Phenotypes; Proteins; Proto-Oncogene Proteins p21(ras) - metabolism; Recognition; Repair; Retina; Retinoblastoma; Retinoblastoma Protein - metabolism; Senescence; Stress, Physiological; Stresses; T-Lymphocytes, Cytotoxic - immunology; Transcription factors; Transcription, Genetic; Tumor suppression; Tumors