Skin-resident dendritic cells mediate postoperative pain via CCR4 on sensory neurons

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 119; no. 4; p. 1
• Main Authors: Silva, Jaqueline Raymondi, Iftinca, Mircea, Fernandes Gomes, Francisco I, Segal, Julia P, Smith, Olivia M A, Bannerman, Courtney A, Silva Mendes, Atlante, Defaye, Manon, Robinson, Madeline E C, Gilron, Ian, Cunha, Thiago Mattar, Altier, Christophe, Ghasemlou, Nader
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 25.01.2022
• Subjects: Action Potentials; Animals; Biological Sciences; Biomarkers; CCL17 protein; CCL22 protein; Cell interactions; Chemokine CCL17 - genetics; Chemokine CCL17 - metabolism; Chemokine CCL22 - genetics; Chemokine CCL22 - metabolism; Chemokines; Dendritic cells; Dendritic structure; Disease Models, Animal; Disease Susceptibility; Excitability; Gene Expression Profiling; Hypersensitivity; Immune system; Inflammation; Injuries; Langerhans cells; Langerhans Cells - immunology; Langerhans Cells - metabolism; Mice; Myeloid cells; Neurons; Pain; Pain, Postoperative - diagnosis; Pain, Postoperative - etiology; Pain, Postoperative - metabolism; Pathogenesis; Receptors, CCR4 - metabolism; Sensory neurons; Sensory Receptor Cells - metabolism; Signal Transduction; siRNA; Skin; Tissues; Transgenic mice; pain; cytokines; myeloid cells; electrophysiology; inflammation

Inflammatory pain, such as hypersensitivity resulting from surgical tissue injury, occurs as a result of interactions between the immune and nervous systems with the orchestrated recruitment and activation of tissue-resident and circulating immune cells to the site of injury. Our previous studies id...