Distinctive clinical presentation and pathogenic specificities of anti-AK5 encephalitis

• Published in: Brain (London, England : 1878) Vol. 144; no. 9; pp. 2709 - 2721
• Main Authors: Muñiz-Castrillo, Sergio, Hedou, Julien Jacques, Ambati, Aditya, Jones, David, Vogrig, Alberto, Pinto, Anne-Laurie, Benaiteau, Marie, de Broucker, Thomas, Fechtenbaum, Laura, Labauge, Pierre, Murnane, Matthew, Nocon, Claire, Taifas, Irina, Vialatte de Pémille, Clément, Psimaras, Dimitri, Joubert, Bastien, Dubois, Valérie, Wucher, Valentin, Desestret, Virginie, Mignot, Emmanuel, Honnorat, Jérôme
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 22.10.2021
• Subjects: Adenylate Kinase; Adenylate Kinase - blood; Adenylate Kinase - cerebrospinal fluid; Aged; Aged, 80 and over; Autoantibodies; Autoantibodies - blood; Autoantibodies - cerebrospinal fluid; Female; Humans; Life Sciences; Limbic Encephalitis; Limbic Encephalitis - blood; Limbic Encephalitis - cerebrospinal fluid; Limbic Encephalitis - diagnostic imaging; Male; Middle Aged; Neurons and Cognition; Original; Proteomics; Proteomics - methods; adenylate kinase 5; human leucocyte antigen; limbic encephalitis; proteomics; Human leucocyte antigen; Limbic encephalitis; Proteomics; Adenylate kinase 5

Limbic encephalitis with antibodies against adenylate kinase 5 (AK5) has been difficult to characterize because of its rarity. In this study, we identified 10 new cases and reviewed 16 previously reported patients, investigating clinical features, IgG subclasses, human leucocyte antigen and CSF prot...