Spike ripples localize the epileptogenic zone best: an international intracranial study

• Published in: Brain (London, England : 1878) Vol. 147; no. 7; pp. 2496 - 2506
• Main Authors: Shi, Wen, Shaw, Dana, Walsh, Katherine G, Han, Xue, Eden, Uri T, Richardson, Robert M, Gliske, Stephen V, Jacobs, Julia, Brinkmann, Benjamin H, Worrell, Gregory A, Stacey, William C, Frauscher, Birgit, Thomas, John, Kramer, Mark A, Chu, Catherine J
• Format: Journal Article
• Language: English
• Published: UK Oxford University Press 05.07.2024
• Subjects: Adolescent; Adult; Brain - physiopathology; Brain Waves - physiology; Child; Electrocorticography - methods; Electroencephalography - methods; Epilepsy - physiopathology; Epilepsy - surgery; Female; Humans; Male; Middle Aged; Original; Young Adult; epilepsy surgery; fast ripple; spike-gamma; automated detector; high frequency oscillations; interictal biomarker

Abstract We evaluated whether spike ripples, the combination of epileptiform spikes and ripples, provide a reliable and improved biomarker for the epileptogenic zone compared with other leading interictal biomarkers in a multicentre, international study. We first validated an automated spike ripple...