Mechanism-based design of agents that selectively target drug-resistant glioma - Lin, Kingson; Gueble, Susan E.; Sundaram, Ranjini K.; Huseman, Eric D.; Bindra, Ranjit S.; Herzon, Seth B. (Science (American Association for the Advancement of Science), 2022)
Keywords: Antineoplastic Agents, Alkylating - chemistry; Antineoplastic Agents, Alkylating - pharmacology; Antineoplastic Agents, Alkylating - therapeutic use; Brain; Brain cancer; Brain Neoplasms - drug therapy; Brain Neoplasms - genetics; Brain tumors; Cancer; Cell Line, Tumor; Chemotherapy; Dacarbazine - pharmacology; Dacarbazine - therapeutic use; Deoxyribonucleic acid; DNA; DNA Methylation - genetics; DNA Modification Methylases - genetics; DNA repair; DNA Repair - genetics; DNA Repair Enzymes - genetics; Drug Design; Drug development; Drug resistance; Drug Resistance, Neoplasm - genetics; Glial cells; Glioblastoma; Glioblastoma - drug therapy; Glioblastoma - genetics; Glioma; Humans; Lesions; Repair; Spinal cord; Temozolomide; Temozolomide - pharmacology; Temozolomide - therapeutic use; Tumor Suppressor Proteins - genetics; Tumors