Adjusting plasma ferritin concentrations to remove the effects of subclinical inflammation in the assessment of iron deficiency: a meta-analysis

• Published in: The American journal of clinical nutrition Vol. 92; no. 3; pp. 546 - 555
• Main Authors: Thurnham, David I, McCabe, Linda D, Haldar, Sumanto, Wieringa, Frank T, Northrop-Clewes, Christine A, McCabe, George P
• Format: Journal Article
• Language: English
• Published: United States American Society for Clinical Nutrition, Inc 01.09.2010
• Subjects: accuracy; Adult; Age Factors; Anemia, Iron-Deficiency; Anemia, Iron-Deficiency - blood; Anemia, Iron-Deficiency - complications; Anemia, Iron-Deficiency - diagnosis; Biomarkers; Biomarkers - blood; blood; C-reactive protein; C-Reactive Protein - metabolism; Child; children; complications; Convalescence; diagnosis; Diet; dietary minerals; disease course; disease diagnosis; Female; ferritin; Ferritins; Ferritins - blood; Glycoproteins; Humans; Infant; infants; Infectious Disease Incubation Period; inflammation; Inflammation - blood; Inflammation - complications; Iron; Male; measurement; men; Meta-analysis; metabolism; nutrient deficiencies; Nutrition; nutritional status; Orosomucoid; Orosomucoid - metabolism; Plasma; reference standards; women

The World Health Organization recommends serum ferritin concentrations as the best indicator of iron deficiency (ID). Unfortunately, ferritin increases with infections; hence, the prevalence of ID is underestimated. The objective was to estimate the increase in ferritin in 32 studies of apparently h...