Retrieval of the mrp2 Gene Encoded Conjugate Export Pump from the Canalicular Membrane Contributes to Cholestasis Induced by tert-Butyl Hydroperoxide and Chloro-Dinitrobenzene
Oxidative stress is known to induce cholestasis, but the underlying mechanisms are poorly understood. In this study we have characterized the short-term effects of tert-butyl hydroperoxide (t-BOOH)- and 1-chloro-2,4-dinitrobenzene (CDNB) on the mrp2 gene encoded canalicular export pump (Mrp2). The e...
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Published in | Biological chemistry Vol. 381; no. 5-6; pp. 487 - 495 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Germany
Walter de Gruyter
01.05.2000
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Subjects | |
Online Access | Get full text |
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