The Role of Methanogenic Archaea in Inflammatory Bowel Disease—A Review

Methanogenic archaea are a part of the commensal gut microbiota responsible for hydrogen sink and the efficient production of short-chain fatty acids. Dysbiosis of methanogens is suspected to play a role in pathogenesis of variety of diseases, including inflammatory bowel disease (IBD). Unlike bacte...

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Published inJournal of personalized medicine Vol. 14; no. 2; p. 196
Main Authors Cisek, Agata Anna, Szymańska, Edyta, Aleksandrzak-Piekarczyk, Tamara, Cukrowska, Bożena
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 01.02.2024
Subjects
Age groups
Bacteria
Breastfeeding & lactation
Colon
Comparative analysis
Dysbacteriosis
Fatty acids
Hydrogen
Inflammation
Inflammatory bowel disease
Inflammatory bowel diseases
Intestinal microflora
Intestine
Methanogenic archaea
Methanogenic bacteria
Microbiota
Microbiota (Symbiotic organisms)
Microorganisms
Older people
Pathogenesis
Pediatrics
Small intestine
Ulcerative colitis
Poland
Canada
methanogenic archaea
IBD
ulcerative colitis
pediatric diseases
methanogens
inflammatory bowel disease
Crohn’s disease
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Abstract Methanogenic archaea are a part of the commensal gut microbiota responsible for hydrogen sink and the efficient production of short-chain fatty acids. Dysbiosis of methanogens is suspected to play a role in pathogenesis of variety of diseases, including inflammatory bowel disease (IBD). Unlike bacteria, the diversity of archaea seems to be higher in IBD patients compared to healthy subjects, whereas the prevalence and abundance of gut methanogens declines in IBD, especially in ulcerative colitis. To date, studies focusing on methanogens in pediatric IBD are very limited; nevertheless, the preliminary results provide some evidence that methanogens may be influenced by the chronic inflammatory process in IBD. In this review, we demonstrated the development and diversity of the methanogenic community in IBD, both in adults and children.
AbstractList Methanogenic archaea are a part of the commensal gut microbiota responsible for hydrogen sink and the efficient production of short-chain fatty acids. Dysbiosis of methanogens is suspected to play a role in pathogenesis of variety of diseases, including inflammatory bowel disease (IBD). Unlike bacteria, the diversity of archaea seems to be higher in IBD patients compared to healthy subjects, whereas the prevalence and abundance of gut methanogens declines in IBD, especially in ulcerative colitis. To date, studies focusing on methanogens in pediatric IBD are very limited; nevertheless, the preliminary results provide some evidence that methanogens may be influenced by the chronic inflammatory process in IBD. In this review, we demonstrated the development and diversity of the methanogenic community in IBD, both in adults and children.
Methanogenic archaea are a part of the commensal gut microbiota responsible for hydrogen sink and the efficient production of short-chain fatty acids. Dysbiosis of methanogens is suspected to play a role in pathogenesis of variety of diseases, including inflammatory bowel disease (IBD). Unlike bacteria, the diversity of archaea seems to be higher in IBD patients compared to healthy subjects, whereas the prevalence and abundance of gut methanogens declines in IBD, especially in ulcerative colitis. To date, studies focusing on methanogens in pediatric IBD are very limited; nevertheless, the preliminary results provide some evidence that methanogens may be influenced by the chronic inflammatory process in IBD. In this review, we demonstrated the development and diversity of the methanogenic community in IBD, both in adults and children.Methanogenic archaea are a part of the commensal gut microbiota responsible for hydrogen sink and the efficient production of short-chain fatty acids. Dysbiosis of methanogens is suspected to play a role in pathogenesis of variety of diseases, including inflammatory bowel disease (IBD). Unlike bacteria, the diversity of archaea seems to be higher in IBD patients compared to healthy subjects, whereas the prevalence and abundance of gut methanogens declines in IBD, especially in ulcerative colitis. To date, studies focusing on methanogens in pediatric IBD are very limited; nevertheless, the preliminary results provide some evidence that methanogens may be influenced by the chronic inflammatory process in IBD. In this review, we demonstrated the development and diversity of the methanogenic community in IBD, both in adults and children.
Audience Academic
Author Aleksandrzak-Piekarczyk, Tamara
Cukrowska, Bożena
Szymańska, Edyta
Cisek, Agata Anna
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Keywords methanogenic archaea
IBD
ulcerative colitis
pediatric diseases
methanogens
inflammatory bowel disease
Crohn’s disease
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SubjectTerms Age groups
Bacteria
Breastfeeding & lactation
Colon
Comparative analysis
Dysbacteriosis
Fatty acids
Hydrogen
Inflammation
Inflammatory bowel disease
Inflammatory bowel diseases
Intestinal microflora
Intestine
Methanogenic archaea
Methanogenic bacteria
Microbiota
Microbiota (Symbiotic organisms)
Microorganisms
Older people
Pathogenesis
Pediatrics
Small intestine
Ulcerative colitis
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Title The Role of Methanogenic Archaea in Inflammatory Bowel Disease—A Review
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