Tumor Cells and Cancer-Associated Fibroblasts: An Updated Metabolic Perspective

• Published in: Cancers Vol. 13; no. 3; p. 399
• Main Authors: Gentric, Géraldine, Mechta-Grigoriou, Fatima
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 22.01.2021; MDPI
• Subjects: Amino acids; Biosynthesis; Breast cancer; Cancer; Carbon; Carbon sources; Fibroblasts; Glucose; Metabolic pathways; Metabolism; Metabolites; Molecular modelling; Oxidative stress; Phosphorylation; Respiration; Review; Tumor cells; Tumor microenvironment; Tumors; cancer cell; fibroblast; crosstalk; CAF; OXPHOS; metabolism; tumor microenvironment; heterogeneity
• ISSN: 2072-6694; 2072-6694
• DOI: 10.3390/cancers13030399

During the past decades, metabolism and redox imbalance have gained considerable attention in the cancer field. In addition to the well-known Warburg effect occurring in tumor cells, numerous other metabolic deregulations have now been reported. Indeed, metabolic reprograming in cancer is much more...