Spot and Cumulative Urine Samples Are Suitable Replacements for 24-Hour Urine Collections for Objective Measures of Dietary Exposure in Adults Using Metabolite Biomarkers

• Published in: The Journal of nutrition Vol. 149; no. 10; pp. 1692 - 1700
• Main Authors: Wilson, Thomas, Garcia-Perez, Isabel, Posma, Joram M, Lloyd, Amanda J, Chambers, Edward S, Tailliart, Kathleen, Zubair, Hassan, Beckmann, Manfred, Mathers, John C, Holmes, Elaine, Frost, Gary, Draper, John
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.10.2019; Oxford University Press; American Institute of Nutrition
• Subjects: 24-h urine; Adult; Aged; Biomarkers; Biomarkers - urine; Chromatography; Classification; Collection; Data collection; Diet; Dietary Exposure; Dietary intake; Exposure; Female; Fingerprinting; Food intake; high-resolution mass spectrometry; Humans; Liquid chromatography; Magnetic resonance spectroscopy; Male; Mass spectrometry; Mass spectroscopy; Meals; Metabolites; Metabolome; metabolomics; Middle Aged; NMR; Nuclear magnetic resonance; nuclear magnetic resonance spectroscopy; Quadrupoles; Reproducibility of Results; spot urine; Urine; Urine Specimen Collection - methods; Young Adult; spot urine; high-resolution mass spectrometry; ROC; nuclear magnetic resonance spectroscopy; FIE-HRMS; MRM; PCA; CS; PB; dietary intake; PD; 1H-NMR; metabolomics; UHPLC; 24-h urine; PL; DHPPA; MDS

Measurement of multiple food intake exposure biomarkers in urine may offer an objective method for monitoring diet. The potential of spot and cumulative urine samples that have reduced burden on participants as replacements for 24-h urine collections has not been evaluated. The aim of this study was...