Lung Tumorigenesis Alters the Expression of Slit2-exon15 Splicing Variants in Tumor Microenvironment

• Published in: Cancers Vol. 11; no. 2; p. 166
• Main Authors: Wu, Ming-Fang, Chuang, Cheng-Yen, Lin, Pinpin, Chen, Wei-Ting, Su, Shang-Er, Liao, Chen-Yi, Jan, Ming-Shiou, Chang, Jinghua Tsai
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.02.2019; MDPI
• Subjects: Angiogenesis; Brain; Cell growth; Inflammation; Injection; Isoforms; Lipopolysaccharides; Lung cancer; Metastasis; Pneumothorax; Polymerase chain reaction; Roles; Transgenic mice; Tumor microenvironment; Tumorigenesis; Tumors; Veins & arteries; LPS treatment; lung cancer; inflammation; Slit2 splicing variants; tumor microenvironment; kRasG12D; pneumothorax

Slit2 expression is downregulated in various cancers, including lung cancer. We identified two Slit2 splicing variants at exon15—Slit2-WT and Slit2-ΔE15. In the RT-PCR analyses, the Slit2-WT isoform was predominantly expressed in all the lung cancer specimens and in their normal lung counterparts, w...