Atopobium vaginae triggers an innate immune response in an in vitro model of bacterial vaginosis

• Published in: Microbes and infection Vol. 10; no. 4; pp. 439 - 446
• Main Authors: Libby, Erika K., Pascal, Kristen E., Mordechai, Eli, Adelson, Martin E., Trama, Jason P.
• Format: Journal Article
• Language: English
• Published: Lausanne Elsevier SAS 01.04.2008; Amsterdam Elsevier; Paris
• Subjects: Actinobacteria - immunology; Atopobium vaginae; Bacteria; Bacterial vaginosis; beta-Defensins - biosynthesis; beta-Defensins - genetics; Biological and medical sciences; Cell Line; Epithelial Cells - immunology; Epithelial Cells - microbiology; Female; Fundamental and applied biological sciences. Psychology; Gardnerella vaginalis; Gardnerella vaginalis - immunology; Gene Expression Profiling; Humans; Immunity, Innate; Innate immunity; Interleukin-6 - metabolism; Interleukin-8 - metabolism; Lactobacillus - immunology; Lactobacillus crispatus; Microbiology; Myeloid Differentiation Factor 88 - immunology; NF-kappa B - immunology; RNA, Messenger - biosynthesis; Toll-Like Receptor 2 - immunology; Toll-like receptors; Vaginal epithelial cells; Vaginosis, Bacterial - immunology; Vaginosis, Bacterial - microbiology; Atopobium vaginae; Toll-like receptors; Bacterial vaginosis; Vaginal epithelial cells; Innate immunity; Immune response; Vagina; Vaginal diseases; Natural immunity; Toll like receptor; In vitro; Female genital diseases; Infection; Bacteriosis; Epithelial cell; Models

Bacterial vaginosis is the most common vaginal disorder among women of reproductive age. The pathogenesis of bacterial vaginosis is poorly understood, but is defined by a transition in the vaginal flora from the predominant Lactobacillus species to other bacterial species such as Atopobium vaginae a...