Mosaic RBD nanoparticles protect against challenge by diverse sarbecoviruses in animal models

• Published in: Science (American Association for the Advancement of Science) Vol. 377; no. 6606; p. eabq0839
• Main Authors: Cohen, Alexander A., van Doremalen, Neeltje, Greaney, Allison J., Andersen, Hanne, Sharma, Ankur, Starr, Tyler N., Keeffe, Jennifer R., Fan, Chengcheng, Schulz, Jonathan E., Gnanapragasam, Priyanthi N. P., Kakutani, Leesa M., West, Anthony P., Saturday, Greg, Lee, Yu E., Gao, Han, Jette, Claudia A., Lewis, Mark G., Tan, Tiong K., Townsend, Alain R., Bloom, Jesse D., Munster, Vincent J., Bjorkman, Pamela J.
• Format: Journal Article
• Language: English
• Published: United States The American Association for the Advancement of Science 05.08.2022; American Association for the Advancement of Science
• Subjects: Animal models; Animals; Antibodies; Antibodies, Neutralizing - immunology; Antibodies, Viral - immunology; Antisera; Avidity; Betacoronavirus - immunology; Binding; Coronavirus Infections - prevention & control; Coronaviruses; COVID-19; COVID-19 vaccines; Disease Models, Animal; Domains; Epitope mapping; Epitopes - chemistry; Epitopes - immunology; Epitopes - therapeutic use; Global health; Immunization; Immunodominance; Immunology; Lymphocytes B; Macaca; Mice; Microbio; Monoclonal antibodies; Mosaics; Nanoparticles; Nanoparticles - therapeutic use; Neutralization; Pandemics; Protein Domains - immunology; Public health; Receptors; Respiratory diseases; Sarbecovirus; SARS-CoV-2 - immunology; Severe acute respiratory syndrome coronavirus 2; Spike Glycoprotein, Coronavirus - immunology; Trimers; Vaccines; Viral diseases; Zoonoses - prevention & control; Zoonoses - virology

To combat future severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants and spillovers of SARS-like betacoronaviruses (sarbecoviruses) threatening global health, we designed mosaic nanoparticles that present randomly arranged sarbecovirus spike receptor-binding domains (RBDs) to elici...