Mosaic RBD nanoparticles protect against challenge by diverse sarbecoviruses in animal models - Cohen, Alexander A.; van Doremalen, Neeltje; Greaney, Allison J.; Andersen, Hanne; Sharma, Ankur; Starr, Tyler N.; Keeffe, Jennifer R.; Fan, Chengcheng; Schulz, Jonathan E.; Gnanapragasam, Priyanthi N. P.; Kakutani, Leesa M.; West, Anthony P.; et al. (Science (American Association for the Advancement of Science), 2022)
Keywords: Animal models; Animals; Antibodies; Antibodies, Neutralizing - immunology; Antibodies, Viral - immunology; Antisera; Avidity; Betacoronavirus - immunology; Binding; Coronavirus Infections - prevention & control; Coronaviruses; COVID-19; COVID-19 vaccines; Disease Models, Animal; Domains; Epitope mapping; Epitopes - chemistry; Epitopes - immunology; Epitopes - therapeutic use; Global health; Immunization; Immunodominance; Immunology; Lymphocytes B; Macaca; Mice; Microbio; Monoclonal antibodies; Mosaics; Nanoparticles; Nanoparticles - therapeutic use; Neutralization; Pandemics; Protein Domains - immunology; Public health; Receptors; Respiratory diseases; Sarbecovirus; SARS-CoV-2 - immunology; Severe acute respiratory syndrome coronavirus 2; Spike Glycoprotein, Coronavirus - immunology; Trimers; Vaccines; Viral diseases; Zoonoses - prevention & control; Zoonoses - virology