Targeting ectromelia virus and TNF/NF-κB or STAT3 signaling for effective treatment of viral pneumonia

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 119; no. 8
• Main Authors: Pandey, Pratikshya, Al Rumaih, Zahrah, Kels, Ma Junaliah Tuazon, Ng, Esther, Kc, Rajendra, Chaudhri, Geeta, Karupiah, Gunasegaran
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 22.02.2022
• Subjects: Animals; Anti-Inflammatory Agents, Non-Steroidal - administration & dosage; Antiviral agents; Antiviral Agents - pharmacology; Antiviral Agents - therapeutic use; Biological Sciences; Cell Line; Chemokines; Chlorocebus aethiops; Cidofovir; Cidofovir - pharmacology; Cidofovir - therapeutic use; Combined treatment; Coronaviruses; Cytokines; Cytokines - metabolism; Drug Evaluation, Preclinical; Drug Therapy, Combination; Ectromelia virus - drug effects; Etanercept; Etanercept - administration & dosage; Female; Health services; IL-1β; Infections; Inflammation; Influenza A; Interleukin 12; Interleukin 6; Lung - drug effects; Lung - metabolism; Lung diseases; Lungs; Mice; Mice, Inbred C57BL; Morbidity; NF-kappa B - metabolism; NF-κB protein; Pandemics; Pathology; Pneumonia; Pneumonia, Viral - drug therapy; Pneumonia, Viral - metabolism; Public health; Respiratory diseases; Severe acute respiratory syndrome; Severe acute respiratory syndrome coronavirus 2; Signal transduction; Signal Transduction - drug effects; Signaling; Signs and symptoms; Stat3 protein; STAT3 Transcription Factor - metabolism; Tumor necrosis factor; Tumor Necrosis Factor-alpha - antagonists & inhibitors; Tumor necrosis factor-TNF; Viral diseases; Viral Load - drug effects; Viruses; TNF/NF-κB and STAT3 signaling pathways; combined antiviral and anti-inflammatory drug treatment; respiratory ectromelia virus infection; dysregulated inflammatory cytokine response; viral pneumonia

Viral causes of pneumonia pose constant threats to global public health, but there are no specific treatments currently available for the condition. Antivirals are ineffective when administered late after the onset of symptoms. Pneumonia is caused by an exaggerated inflammatory cytokine response to...