Patient-Related Factors Predicting Stent Thrombosis in Percutaneous Coronary Interventions

Over the past four decades, percutaneous coronary intervention (PCI) safety and efficacy have significantly improved, particularly with the advent of the drug-eluting stent (DES). First-generation DESs reduced in-stent restenosis rates and targeted lesion revascularization; however, safety issues em...

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Published inJournal of clinical medicine Vol. 12; no. 23; p. 7367
Main Authors Anghel, Larisa, Tudurachi, Bogdan-Sorin, Tudurachi, Andreea, Zăvoi, Alexandra, Clement, Alexandra, Roungos, Alexandros, Benchea, Laura-Cătălina, Zota, Ioana Mădălina, Prisacariu, Cristina, Sascău, Radu Andy, Stătescu, Cristian
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 28.11.2023
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Abstract Over the past four decades, percutaneous coronary intervention (PCI) safety and efficacy have significantly improved, particularly with the advent of the drug-eluting stent (DES). First-generation DESs reduced in-stent restenosis rates and targeted lesion revascularization; however, safety issues emerged, due to high incidences of stent thrombosis (ST) linked to death, myocardial infarction, and repeat revascularization. Second-generation DESs were developed to overcome these issues, reducing late-thrombotic-event risk while maintaining anti-restenosis efficacy. Nevertheless, ST still occurs with second-generation DES use. Stent thrombosis etiology is multifaceted, encompassing lesion-, patient-, procedural-, and stent-related factors. Overall, most early-stent-thrombosis cases are linked to procedural and patient-related aspects. Factors like premature discontinuation of dual antiplatelet therapy, resistance to clopidogrel, smoking, diabetes mellitus, malignancy, reduced ejection fraction or undertaking coronary angioplasty for an acute coronary syndrome can increase the risk of stent thrombosis. The aim of this study is to assess patient-related factors that potentially heighten the risk of stent thrombosis, with the objective of pinpointing and addressing modifiable contributors to this risk. By focusing on both patient- and procedure-related factors, a multifaceted approach to coronary revascularization can help minimize complications and maximize long-term benefits in managing ST.
AbstractList Over the past four decades, percutaneous coronary intervention (PCI) safety and efficacy have significantly improved, particularly with the advent of the drug-eluting stent (DES). First-generation DESs reduced in-stent restenosis rates and targeted lesion revascularization; however, safety issues emerged, due to high incidences of stent thrombosis (ST) linked to death, myocardial infarction, and repeat revascularization. Second-generation DESs were developed to overcome these issues, reducing late-thrombotic-event risk while maintaining anti-restenosis efficacy. Nevertheless, ST still occurs with second-generation DES use. Stent thrombosis etiology is multifaceted, encompassing lesion-, patient-, procedural-, and stent-related factors. Overall, most early-stent-thrombosis cases are linked to procedural and patient-related aspects. Factors like premature discontinuation of dual antiplatelet therapy, resistance to clopidogrel, smoking, diabetes mellitus, malignancy, reduced ejection fraction or undertaking coronary angioplasty for an acute coronary syndrome can increase the risk of stent thrombosis. The aim of this study is to assess patient-related factors that potentially heighten the risk of stent thrombosis, with the objective of pinpointing and addressing modifiable contributors to this risk. By focusing on both patient- and procedure-related factors, a multifaceted approach to coronary revascularization can help minimize complications and maximize long-term benefits in managing ST.
Audience Academic
Author Zăvoi, Alexandra
Stătescu, Cristian
Clement, Alexandra
Prisacariu, Cristina
Anghel, Larisa
Tudurachi, Bogdan-Sorin
Roungos, Alexandros
Sascău, Radu Andy
Tudurachi, Andreea
Benchea, Laura-Cătălina
Zota, Ioana Mădălina
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  surname: Benchea
  fullname: Benchea, Laura-Cătălina
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percutaneous coronary intervention
heart attack
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stent thrombosis
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Snippet Over the past four decades, percutaneous coronary intervention (PCI) safety and efficacy have significantly improved, particularly with the advent of the...
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StartPage 7367
SubjectTerms Acute coronary syndromes
Aspirin
Blood clot
Cardiovascular disease
Clopidogrel
Complications
Complications and side effects
Coronary artery bypass
Coronary vessels
Development and progression
Diabetes
Drug-eluting stents
Heart attack
Heart attacks
Ischemia
Medical research
Medicine, Experimental
Mortality
Patient compliance
Patients
Risk factors
Stent (Surgery)
Stents
Stroke
Surgery
Thrombosis
Ticagrelor
Transluminal angioplasty
Vein & artery diseases
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Title Patient-Related Factors Predicting Stent Thrombosis in Percutaneous Coronary Interventions
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