Determination of nilvadipine in human plasma by capillary column gas chromatography—negative-ion chemical-ionization mass spectrometry
A highly sensitive and specific method for the determination of nilvadipine, a new dihydropyridine calcium antagonist, in human plasma is described. A deuterated analogue of nilvadipine is added to the plasma as an internal standard. The agent and its internal standard are extracted at pH 9 from the...
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| Published in | Journal of chromatography Vol. 345; no. 1; pp. 51 - 58 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
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Elsevier B.V
1985
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| Abstract | A highly sensitive and specific method for the determination of nilvadipine, a new dihydropyridine calcium antagonist, in human plasma is described. A deuterated analogue of nilvadipine is added to the plasma as an internal standard. The agent and its internal standard are extracted at pH 9 from the plasma into a benzene—
n-hexane (1:1) mixture. The extract is analysed by fused-silica capillary column gas chromatography—negative-ion chemical-ionization mass spectrometry with methane as the reagent gas. The mass spectrometer is set to monitor the negative molecular ions of the agent and internal standard. Quantitation is possible down to 0.01 ng/ml using 1 ml of plasma. The coefficients of variation of the method are 6.4 and 2.1% at the 0.01 and 0.1 ng/ml levels, respectively. Plasma levels obtained with this method are given for four healthy volunteers who had received a 6-mg oral dose of nilvadipine. |
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| AbstractList | A highly sensitive and specific method for the determination of nilvadipine, a new dihydropyridine calcium antagonist, in human plasma is described. A deuterated analogue of nilvadipine is added to the plasma as an internal standard. The agent and its internal standard are extracted at pH 9 from the plasma into a benzene—
n-hexane (1:1) mixture. The extract is analysed by fused-silica capillary column gas chromatography—negative-ion chemical-ionization mass spectrometry with methane as the reagent gas. The mass spectrometer is set to monitor the negative molecular ions of the agent and internal standard. Quantitation is possible down to 0.01 ng/ml using 1 ml of plasma. The coefficients of variation of the method are 6.4 and 2.1% at the 0.01 and 0.1 ng/ml levels, respectively. Plasma levels obtained with this method are given for four healthy volunteers who had received a 6-mg oral dose of nilvadipine. A highly sensitive and specific method for the determination of nilvadipine, a new dihydropyridine calcium antagonist, in human plasma is described. A deuterated analogue of nilvadipine is added to the plasma as an internal standard. The agent and its internal standard are extracted at pH 9 from the plasma into a benzene--n-hexane (1:1) mixture. The extract is analysed by fused-silica capillary column gas chromatography--negative-ion chemical-ionization mass spectrometry with methane as the reagent gas. The mass spectrometer is set to monitor the negative molecular ions of the agent and internal standard. Quantitation is possible down to 0.01 ng/ml using 1 ml of plasma. The coefficients of variation of the method are 6.4 and 2.1% at the 0.01 and 0.1 ng/ml levels, respectively. Plasma levels obtained with this method are given for four healthy volunteers who had received a 6-mg oral dose of nilvadipine. |
| Author | Noguchi, Hideyo Tokuma, Yoji Fujiwara, Tomoichi |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/4086588$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1002/j.1552-4604.1983.tb02734.x 10.1002/bms.1200090306 10.1002/bms.1200050310 10.1248/cpb.28.1 10.1002/bms.1200110110 10.1248/cpb.30.3807 10.1016/0163-7258(83)90040-2 10.1016/0021-9673(75)85010-2 10.1093/clinchem/29.1.158 10.1093/chromsci/21.9.415 10.1016/S0378-4347(00)83318-6 10.1016/S0378-4347(00)82066-6 10.1016/0024-3205(83)90351-X 10.1097/00005344-198311000-00024 10.1016/S0021-9673(01)80450-7 10.1016/S0378-4347(00)80106-1 10.1016/0014-2999(82)90192-3 10.1016/S0021-9673(00)80344-1 10.1021/ac00229a012 10.1021/ac60209a034 10.1016/S0378-4347(00)81871-X 10.1002/bms.1200110813 10.1021/ac50035a017 |
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| SubjectTerms | Calcium Channel Blockers - blood Drug Stability Electrochemistry Gas Chromatography-Mass Spectrometry Humans Nifedipine - analogs & derivatives Nifedipine - blood Solvents |
| Title | Determination of nilvadipine in human plasma by capillary column gas chromatography—negative-ion chemical-ionization mass spectrometry |
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