Cadherins in development: cell adhesion, sorting, and tissue morphogenesis

• Published in: Genes & development Vol. 20; no. 23; pp. 3199 - 3214
• Main Authors: Halbleib, Jennifer M., Nelson, W. James
• Format: Journal Article
• Language: English
• Published: United States 01.12.2006
• Subjects: Animals; Biological Evolution; Cadherins - genetics; Cadherins - physiology; Cell Adhesion - physiology; Gene Expression Regulation, Developmental; Humans; Morphogenesis - physiology; Nervous System - embryology; Nervous System - growth & development; Vertebrates - embryology; Vertebrates - growth & development

Tissue morphogenesis during development is dependent on activities of the cadherin family of cell–cell adhesion proteins that includes classical cadherins, protocadherins, and atypical cadherins (Fat, Dachsous, and Flamingo). The extracellular domain of cadherins contains characteristic repeats that...