Association between Circulating Fibroblast Growth Factor 21 and Aggressiveness in Thyroid Cancer

• Published in: Cancers Vol. 11; no. 8; p. 1154
• Main Authors: Kang, Yea Eun, Kim, Jung Tae, Lim, Mi Ae, Oh, Chan, Liu, Lihua, Jung, Seung-Nam, Won, Ho-Ryun, Lee, Kyungmin, Chang, Jae Won, Yi, Hyon-Seung, Kim, Hyun Jin, Ku, Bon Jeong, Shong, Minho, Koo, Bon Seok
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 12.08.2019; MDPI
• Subjects: Biomarkers; Body mass index; Cell viability; Cholesterol; Energy metabolism; Enzyme inhibitors; Fibroblast growth factor receptors; Fibroblasts; Glucose; Glucose metabolism; Growth factors; Homeostasis; Kinases; Klotho protein; Lipid metabolism; Liver diseases; Mesenchyme; Metabolism; Metastasis; Papillary thyroid cancer; Protein expression; Protein-tyrosine kinase; Serum levels; Thyroid cancer; Tumorigenesis; Tumors; thyroid cancer; cell proliferation; metastasis; FGFR; obesity; FGF21

Fibroblast growth factor 21 (FGF21) plays important roles in regulating glucose, lipid, and energy metabolism; however, its effects in tumors remain poorly understood. To understand the role of FGF21 in regulating tumor aggressiveness in thyroid cancer, serum levels of FGF21 were measured in healthy...