Chronic effects of AJ-9677 on energy expenditure and energy source utilization in rats
The effects of AJ-9677 on metabolic parameters were examined in rats that had or had not been chronically treated with this β3-adrenoceptor agonist. A challenge administration of AJ-9677 increased both the temperature of brown adipose tissue and energy expenditure in both groups of rats. However, wh...
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| Published in | European journal of pharmacology Vol. 519; no. 1-2; pp. 135 - 145 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
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Amsterdam
Elsevier B.V
05.09.2005
Elsevier |
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| Abstract | The effects of AJ-9677 on metabolic parameters were examined in rats that had or had not been chronically treated with this β3-adrenoceptor agonist. A challenge administration of AJ-9677 increased both the temperature of brown adipose tissue and energy expenditure in both groups of rats. However, whereas the former effect was subject to desensitization, the latter effect was augmented by prior chronic administration of AJ-9677. Whereas a challenge administration of AJ-9677 induced a decrease in the respiratory quotient that persisted for at least 15 h in rats pretreated with vehicle, the initial decrease in this parameter lasted for only 4 h in rats pretreated with AJ-9677. These results suggest that, in rats subjected to chronic treatment with AJ-9677, a challenge administration of this drug increased energy expenditure by stimulation not only of fat oxidation but also of glucose oxidation. |
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| AbstractList | The effects of AJ-9677 on metabolic parameters were examined in rats that had or had not been chronically treated with this beta sub(3)-adrenoceptor agonist. A challenge administration of AJ-9677 increased both the temperature of brown adipose tissue and energy expenditure in both groups of rats. However, whereas the former effect was subject to desensitization, the latter effect was augmented by prior chronic administration of AJ-9677. Whereas a challenge administration of AJ-9677 induced a decrease in the respiratory quotient that persisted for at least 15 h in rats pretreated with vehicle, the initial decrease in this parameter lasted for only 4 h in rats pretreated with AJ-9677. These results suggest that, in rats subjected to chronic treatment with AJ-9677, a challenge administration of this drug increased energy expenditure by stimulation not only of fat oxidation but also of glucose oxidation. The effects of AJ-9677 on metabolic parameters were examined in rats that had or had not been chronically treated with this beta3-adrenoceptor agonist. A challenge administration of AJ-9677 increased both the temperature of brown adipose tissue and energy expenditure in both groups of rats. However, whereas the former effect was subject to desensitization, the latter effect was augmented by prior chronic administration of AJ-9677. Whereas a challenge administration of AJ-9677 induced a decrease in the respiratory quotient that persisted for at least 15 h in rats pretreated with vehicle, the initial decrease in this parameter lasted for only 4 h in rats pretreated with AJ-9677. These results suggest that, in rats subjected to chronic treatment with AJ-9677, a challenge administration of this drug increased energy expenditure by stimulation not only of fat oxidation but also of glucose oxidation. The effects of AJ-9677 on metabolic parameters were examined in rats that had or had not been chronically treated with this β3-adrenoceptor agonist. A challenge administration of AJ-9677 increased both the temperature of brown adipose tissue and energy expenditure in both groups of rats. However, whereas the former effect was subject to desensitization, the latter effect was augmented by prior chronic administration of AJ-9677. Whereas a challenge administration of AJ-9677 induced a decrease in the respiratory quotient that persisted for at least 15 h in rats pretreated with vehicle, the initial decrease in this parameter lasted for only 4 h in rats pretreated with AJ-9677. These results suggest that, in rats subjected to chronic treatment with AJ-9677, a challenge administration of this drug increased energy expenditure by stimulation not only of fat oxidation but also of glucose oxidation. |
| Author | Kasuga, Masato Yokoyama, Yuichi Ogawa, Wataru Sugimoto, Tadanori |
| Author_xml | – sequence: 1 givenname: Tadanori surname: Sugimoto fullname: Sugimoto, Tadanori email: tadanori-sugimoto@dainippon-pharm.co.jp organization: Biostatistics, Drug Development Division, Dainippon Pharmaceutical Co. Ltd., 33-94 Enoki-cho, Suita, Osaka 564-0053, Japan – sequence: 2 givenname: Wataru surname: Ogawa fullname: Ogawa, Wataru organization: Department of Clinical Molecular Medicine, Division of Diabetes and Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan – sequence: 3 givenname: Masato surname: Kasuga fullname: Kasuga, Masato organization: Department of Clinical Molecular Medicine, Division of Diabetes and Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan – sequence: 4 givenname: Yuichi surname: Yokoyama fullname: Yokoyama, Yuichi organization: Drug Research Division, Dainippon Pharmaceutical Co. Ltd., 33-94 Enoki-cho, Suita, Osaka 564-0053, Japan |
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| Keywords | Energy expenditure AJ-9677 Respiratory quotient β3-adrenoceptor Vertebrata Chronic Mammalia Rat Animal Rodentia β3-Adrenergic receptor |
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| Title | Chronic effects of AJ-9677 on energy expenditure and energy source utilization in rats |
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