Characterization of the sex-dependent myocardial S -nitrosothiol proteome

• Published in: American journal of physiology. Heart and circulatory physiology Vol. 310; no. 4; pp. H505 - H515
• Main Authors: Shao, Qin, Fallica, Jonathan, Casin, Kevin M., Murphy, Elizabeth, Steenbergen, Charles, Kohr, Mark J.
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 15.02.2016
• Subjects: Animals; Coronary Circulation - drug effects; Cyclophilins - metabolism; Endoplasmic Reticulum - metabolism; Female; Heart - drug effects; Male; Menopause; Mice; Mice, Inbred C57BL; Myocardial Reperfusion Injury - metabolism; Myocardium - metabolism; Nitric Oxide - biosynthesis; Nitric Oxide Synthase Type III - biosynthesis; Peptidyl-Prolyl Isomerase F; Phosphorylation; Physiology; Proteins; Proteome - drug effects; Proteomics; S-Nitrosothiols - metabolism; Sex Characteristics; Signaling and Stress Response; Womens health; ischemia-reperfusion injury; S-nitrosoglutathione reductase; cardioprotection; endothelial nitric oxide synthase; sex differences; S-nitrosylation

Premenopausal women exhibit endogenous cardioprotective signaling mechanisms that are thought to result from the beneficial effects of estrogen, which we have shown to increase protein S-nitrosylation in the heart. S-nitrosylation is a labile protein modification that increases with a number of diff...