Host-Derived Proteinases and Degradation of Dentine Collagen in situ

• Published in: Caries research Vol. 37; no. 1; pp. 58 - 65
• Main Authors: van Strijp, A.J.P., Jansen, D.C., DeGroot, J., ten Cate, J.M., Everts, V.
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland S. Karger AG 01.01.2003
• Subjects: Aged; Animals; Cathepsin B - metabolism; Cattle; Collagen - metabolism; Dentin - enzymology; Dentistry; Electrophoresis, Polyacrylamide Gel; Female; Humans; Male; Matrix Metalloproteinases - metabolism; Middle Aged; Original Paper; Root Caries - enzymology; Saliva - enzymology; Root caries; Cysteine proteinases; Matrix metalloproteinases; Collagen; Dentine; Proteolytic degradation; Saliva

Dentine root caries is a process of demineralization and degradation of the organic matrix by proteinases. In this in situ study, the presence and activity of the matrix metalloproteinases 1, 2 and 9 (MMP-1, MMP-2, MMP-9) in saliva and in completely demineralized dentine specimens were investigated....