Long-term exacerbation by interleukin 13 of IgE-mediated eosinophilia in rats

• Published in: International immunopharmacology Vol. 5; no. 9; pp. 1353 - 1364
• Main Authors: Rossi, Maria Inês Doria, de Oliveira Barreto, Emiliano, Pires, Ana Lúcia Aguiar, Rossi, Maria Isabel Doria, Dias, Vanessa Aparecida Ribeiro, Cordeiro, Renato Sérgio Balão, Martins, Marco Aurélio, Lima, Marcia Coronha Ramos
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01.08.2005; Elsevier
• Subjects: Animals; Biological and medical sciences; Cell Movement; Chemokine CCL11; Chemokines, CC - biosynthesis; Eosinophil infiltration; Eosinophilia - immunology; Eosinophils - immunology; Hypersensitivity, Immediate - immunology; IgE-dependent allergy; IL-13 priming; Immunoglobulin E - immunology; Interleukin-13 - biosynthesis; Interleukin-13 - toxicity; Leukotriene C4 - biosynthesis; Lipoxygenase Inhibitors; Mast cells; Mast Cells - cytology; Mast Cells - immunology; Medical sciences; Pharmacology. Drug treatments; Rats; Rats, Wistar; IL-13 priming; Mast cells; Eosinophil infiltration; IgE-dependent allergy; Immunopathology; Allergy; Rat; IgE; Cytokine; Rodentia; Granulocyte; Priming; Hemopathy; Interleukin 13; Eosinophilia; Long term; Eosinophil; Exacerbation; Vertebrata; Mammalia; Animal; Infiltration; Mast cell

Recent work shows that at least two cycles of antigen challenge applied in a 7-day interval are required to yield tissue eosinophil accumulation in IgE-passively sensitized rats. Since interleukin (IL)-13 is widely regarded as a key mediator in eosinophilic responses associated with mast cells and I...