The tissue is the issue: personalized medicine for non-small cell lung cancer

• Published in: Clinical cancer research Vol. 16; no. 20; pp. 4909 - 4911
• Main Authors: Hirsch, Fred R, Wynes, Murry W, Gandara, David R, Bunn, Jr, Paul A
• Format: Journal Article
• Language: English
• Published: United States 15.10.2010
• Subjects: Carcinoma, Non-Small-Cell Lung - drug therapy; Carcinoma, Non-Small-Cell Lung - genetics; Carcinoma, Non-Small-Cell Lung - metabolism; Humans; Immunohistochemistry; Lung Neoplasms - drug therapy; Lung Neoplasms - genetics; Lung Neoplasms - metabolism; Molecular Targeted Therapy - methods; Precision Medicine - methods

The development of molecular markers is crucial for improving therapy in advanced non-small cell lung cancer (NSCLC). Here, we review perspectives of biomarker-driven personalized therapy in NSCLC, with particular reference to the detection of EML4-ALK gene rearrangements. Different molecular assays...