Apoptosis—programmed cell death: a role in the aging process?

• Published in: The American journal of clinical nutrition Vol. 55; no. 6; pp. 1208S - 1214S
• Main Authors: Monti, D, Troiano, L, Tropea, F, Grassilli, E, Cossarizza, A, Barozzi, D, Pelloni, MC, Tamassia, MG, Bellomo, G, Franceschi, C
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Bethesda, MD Elsevier Inc 01.06.1992; American Society for Clinical Nutrition
• Subjects: 3-aminobenzamide; Aging; Aging - physiology; apoptosis; Biological and medical sciences; CARNITINA; CARNITINE; cell death; Cell Death - physiology; cells; CELLULE; CELULAS; CINC; CONTAMINANTES; death; Development. Metamorphosis. Moult. Ageing; DNA Damage - physiology; ENVEJECIMIENTO; ENZIMAS; ENZYME; enzymes; Free Radicals; Fundamental and applied biological sciences. Psychology; Humans; MORT; MUERTE; Oxidation-Reduction; Oxygen - metabolism; oxygen free radicals; POLLUANT; Poly(ADP-ribose) Polymerases - physiology; poly(ADP-ribosyl)polymerase; Vertebrates: anatomy and physiology, studies on body, several organs or systems; VIEILLISSEMENT; ZINC; cell death; poly(ADP-ribosyl)polymerase; 3-aminobenzamide; Aging; apoptosis; carnitine; zinc; oxygen free radicals

Cells continuously exposed to genotoxic agents, such as oxygen free radicals (OFRs), deeply involved in the aging process use a variety of cellular defense mechanisms. These defense mechanisms include DNA repair enzymes, antioxidants, poly(ADP-ribosyl)polymerase (pADPRP), and stress proteins and the...