Syntheses of [C]2- and [C]3-trifluoromethyl-4-aminopyridine: potential PET radioligands for demyelinating diseases

• Published in: MedChemComm Vol. 11; no. 1; pp. 1161 - 1167
• Main Authors: Ramos-Torres, Karla M, Zhou, Yu-Peng, Yang, Bo Yeun, Guehl, Nicolas J, Sung-Hyun, Moon, Telu, Sanjay, Normandin, Marc D, Pike, Victor W, Brugarolas, Pedro
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 01.10.2020
• Subjects: Chemistry; Demyelinating diseases; Demyelination; Derivatives; High-performance liquid chromatography; Labeling; Positron emission; Production methods; Pyridines; Radioisotopes; Tomography

Trifluoromethyl groups are of great interest in PET radiopharmaceuticals. Radiolabelled 4-aminopyridine (4AP) derivatives have been proposed for imaging demyelinating diseases. Here, we describe methods for producing 11 C-trifluoromethylated derivatives of 4AP and present early imaging results with...