Enhancing VTA Cav1.3 L-type Ca2+ channel activity promotes cocaine and mood-related behaviors via overlapping AMPA receptor mechanisms in the nucleus accumbens

• Published in: Molecular psychiatry Vol. 22; no. 12; pp. 1735 - 1745
• Main Authors: Martínez-Rivera, A, Hao, J, Tropea, T F, Giordano, T P, Kosovsky, M, Rice, R C, Lee, A, Huganir, R L, Striessnig, J, Addy, N A, Han, S, Rajadhyaksha, A M
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.12.2017; Nature Publishing Group
• Subjects: 631/378; 692/699/476/1414; 692/699/476/5; Analysis; Behavior; Behavioral Sciences; Biological Psychology; Bipolar disorder; Calcium channels; Calcium channels (L-type); Calcium channels (voltage-gated); Calcium permeability; Care and treatment; Caveolin-1; Channel gating; Cocaine; Depression; Depression (Mood disorder); Diagnosis; Dihydropyridine; Dosage and administration; Drug abuse; Genetic aspects; Genetic factors; Human behavior; Medicine; Medicine & Public Health; Mental depression; Molecular modelling; Mood; Mutants; Neurosciences; Nucleus accumbens; original-article; Pharmacotherapy; Phenotypes; Phosphorylation; Place preference conditioning; Psychiatry; Receptor mechanisms; Rodents; Single nucleotide polymorphisms; Single-nucleotide polymorphism; Ventral tegmentum; α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid; α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors

Genetic factors significantly influence susceptibility for substance abuse and mood disorders. Rodent studies have begun to elucidate a role of Ca v 1.3 L-type Ca 2+ channels in neuropsychiatric-related behaviors, such as addictive and depressive-like behaviors. Human studies have also linked the CA...