Effects of datumetine on hippocampal NMDAR activity

• Published in: Toxicology reports Vol. 8; pp. 1131 - 1142
• Main Authors: Ishola, Azeez Olakunle, Imam, Aminu, Ajao, Moyosore Salihu
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.01.2021; Elsevier
• Subjects: Datumetine; Datura; Docking; Hippocampus; NMDAR; Recent trends in environmental toxicology and sustainable agriculture; NMDAR; Docking; Datura; Datumetine; Hippocampus

Datumetine binds with NMDAR altering its calcium current. Acute exposure downregulates NMDAR signalling. [Display omitted] •Datura intoxication induces an amnesic experience.•N-methyl-d-aspartate receptor (NMDAR) is implicated in-memory processing.•Flexible docking showed datumetine binds with NMDAR...